MilliporeSigma™ Complement C4, Human, Protein

Catalog No.	Quantity
20-488-6250UG	250 μg

Catalog No. 20-488-6250UG Supplier MilliporeSigma™ Supplier No. 204886250UG

Description

Native, human C4 complement component. Glycoprotein composed of three non-identical subunits of M.W. of 93kDa (α), 75kDa (β), and 32kDa (γ) linked by disulfide bonds. Present in normal human serum at 400μg/mL. On activation of complement via the classical pathway, the C1s subcomponent of the C1 complex is converted to an active serine protease that cleaves the C4 α-chain at peptide bond 77, resulting in production of C4a (M.W. 8740) and C4b fragments (M.W. 193kDa). The released C4a peptide is one of the three complement-derived anaphylatoxins. The nascent C4b fragment can form a covalent ester bond with target surfaces. This covalent attachment of C4b to target acceptors is required for continuation of activation via classical pathway.

Specifications

• Concentration: Concentration on Label
• Formulation: In PBS, pH 7.2.
• Purification Method: SDS-PAGE
• Quantity: 250 μg
• Immunogen: Complement C4
• Storage Requirements: Following initial thaw, aliquot and freeze (−70°C).
• Regulatory Status: RUO
• Species: Human
• Recombinant: Native
• Form: Liquid
• Purity or Quality Grade: ≥90%