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MilliporeSigma™ Complement iC3b, Human, Protein

Catalog No. 204863250UG Shop All MilliporeSigma Products
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20-486-3250UG 250 μg
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Catalog No. 20-486-3250UG Supplier MilliporeSigma™ Supplier No. 204863250UG
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Description

Native, human iC3b complement component. iC3b is formed by the cleavage of C3b by Factor I in the presence of Factor H, CR1, or membrane cofactor protein. Factor I cleavage of C3b to iC3b inactivates and prevents C3b from functioning in the C3 or C5 convertase enzymes. The iC3b fragment thus produced is a glycoprotein composed of two C3α' polypeptides of M.W. 43kDa and M.W. 63kDa which are disulfide bonded to the intact C3 β-chain (M.W. 75kDa). iC3b interaction with CR3 (CD11b/CD18) receptors present on a variety of white blood cells greatly enhances phagocytosis of iC3b coated target cells or particles.
TRUSTED_SUSTAINABILITY

Specifications

Concentration Concentration on Label
Formulation In PBS, pH 7.2.
Purification Method SDS-PAGE
Quantity 250 μg
Immunogen Complement iC3b
Storage Requirements Following initial thaw, aliquot and freeze (−70°C).
Regulatory Status RUO
Species Human
Recombinant Native
Form Liquid
Purity or Quality Grade ≥90%
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