MilliporeSigma™ NRG1 Isoform SMDF, Human, Recombinant Protein

Manufacturer:  MilliporeSigma™ 49202725UG

Catalog No. 49-202-725UG

Description

Recombinant, human neuregulin 1 (NRG1), isoform SMDF (sensory and motor neuron-derived factor), consisting of amino acids 1-263, 117-296, and 162-296, each fused at the C-terminus to a His·Tag™ sequence and expressed in S. frugiperda Sf21 cells using a baculovirus expression system. The neuregulin (also known as heregulin) family of cytokines is comprised of multiple secreted or membrane-bound isorforms that are produced from the single heregulin gene by alternative splicing and/or usage of different promoters. NRG1 isoform SMDF is a type III isoform with a C-terminal EGF-like domain that interacts with the erbB family of tyrosine kinase receptors. NRG1 isoform SMDF expression has been found to be restricted to the nervous system and is believed to play an important role in the development of the nervous system.

Specifications

• Format: Lyophilized
• Preparation Method: Reconstitute to 100μg/mL with sterile PBS containing ≥1% human or bovine serum albumin.
• Purity: >95%
• Immunogen: NRG1 Isoform SMDF
• Regulatory Status: RUO
• Recombinant: Yes

• Formulation: Lyophilized from 0.2μM filtered PBS, BSA.
• Purification Method: SDS-PAGE
• Quantity: 25μg
• Storage Requirements: Following reconstituion refrigerate (4°C) for short-term storage or aliquot and freeze (−20°C) for long-term storage. Stock solutions are stable for up to 1 month at 4°C or for up to 3 months at −20°C.
• Host Species: Human