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MilliporeSigma™ RAP, Human, Recombinant Protein, E. coli

Catalog No. 55350650UG Shop All MilliporeSigma Products
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55-350-650UG 50 μg
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Description

Recombinant, human RAP fused to GST, expressed in E. coli, and subsequently cleaved with thrombin to remove GST. Antagonizes the ligand binding of certain members of the low-density lipoprotein receptor family such as low density lipoprotein receptor-related protein (LRP) and very low-density lipoprotein (VLDL) receptor. Promotes the proper folding and subsequent exocytic trafficking of the wild-type low density lipoprotein receptor (LDLR) and several of its class 2 mutants. Expressed as a GST-fusion protein that is subsequently cleaved with thrombin. Typical concentrations to block LRP or VLDL receptor are 200-300nM. For antagonism of LDLR, 1μM is recommended.
TRUSTED_SUSTAINABILITY

Specifications

Concentration Concentration on Label
Formulation 150mM NaCl, 100mM Tris-HCl, pH 7.4.
Purification Method SDS-PAGE
Quantity 50 μg
Source E. coli
Immunogen RAP
Storage Requirements Following initial thaw, aliquot and freeze (−70°C).
Regulatory Status RUO
Species Human
Recombinant Recombinant
Form Liquid
Purity or Quality Grade ≥90%
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