MilliporeSigma™ Tissue Plasminogen Activator, Human, Protein

Description

Native tissue plasminogen activator from a human melanoma cell line. A serine protease that contains a single chain of 527 amino acids. Binds to fibrin via lysine binding sites at its amino terminus and activates bound plasminogen. Cleaves plasminogen to form active plasmin, the proteolytic enzyme that dissolves clots. Reported to be involved in neurite outgrowth, regeneration, and migration. Plays an important role in excitotoxin-induced neuronal degeneration.

Specifications

• Formulation: Lyophilized from 100mM PBS, 3.5mg/mL L-arginine, 0.001% Tween™-80 Detergent.
• Preparation Method: Reconstitute with diH₂O to a final concentration of 1mg/mL (e.g., 100μg should be reconstituted in 100μL).
• Purification Method: SDS-PAGE
• Quantity: 100 μg
• Immunogen: Tissue Plasminogen Activator
• Storage Requirements: Following reconstitution, aliquot and freeze (−20°C). Stock solutions are stable for up to 6 months at −20°C.
• Regulatory Status: RUO
• Species: Human
• Recombinant: Native
• Form: Lyophilized
• Purity or Quality Grade: ≥95%