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MilliporeSigma™ Upstate™ Trimethyl-Histone H3 (Lys4)α, Rabbit Monoclonal, ChIP Validated Antibody and Primer Set

Catalog No. 17614MI Shop All MilliporeSigma Products
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Quantity:
25 Assays
Conjugate:
Unconjugated
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Catalog No. Quantity Conjugate
17-614-MI 25 Assays Unconjugated
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Catalog No. 17-614-MI Supplier MilliporeSigma™ Supplier No. 17614
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Description

Rabbit Monoclonal Antibody

Specifically detects Trimethyl-Histone H3 (Lys4)α Clone: in Human, Mammalia, Mouse samples, and it is validated for ChIP, ChIP-seq, Western Blotting

The methylation of histones can occur on two different residues: arginine or lysine. Histone methylation can be associated with transcriptional activation or repression, depending on the methylated residue. Lysine 4 of histone H3 can be mono-, di- or trimethylated by different histone methyltransferases (HMTs) such as SET1 or ASH1. Methylation of Lys4 is often associated with transcriptional activation. The demethylase LSD1 is able to demethylate histone H3 Lys4.
TRUSTED_SUSTAINABILITY

Specifications

Antigen Trimethyl-Histone H3 (Lys4)α
Applications ChIP Assay, ChIP sequencing (ChIP-seq), Western Blot
Classification Monoclonal
Conjugate Unconjugated
Formulation Anti-Trimethyl-Histone H3 (Lys4) recombin-ant rabbit monoclonal IgG. One vial containing 75μL of protein A purified rabbit IgG in storage buffer (0.1M Tris-Glycine pH 7.4, 0.15M NaCl, 0.05% NaN3, with the addition of 40% glycerol.
Normal Rabbit IgG. One vial containing 75μL of normal rabbit IgG.
Control Primers. One vial containing 75μL of 5μM of each primer specific for human GAPDH. FOR: TAC TAG CGG TTT TAC GGG CG REV: TCG AAC AGG AGG AGC AGA GAG CGA
Gene Accession No. Q66I33
Gene Symbols H3F3A, H3F3B, H3F3
Host Species Rabbit
Immunogen The trimethyl-histone H3 (Lys4) antibody is made against a BSA-conjugated, synthetic peptide containing the sequence …RT[me3K]QT… in which me3K corresponds to trimethyl-lysine 4 of human histone H3
Quantity 25 Assays
Regulatory Status RUO
Research Discipline Epigenetics, Nuclear Function
Primary or Secondary Primary
Gene ID (Entrez) NM_003493
Test Specificity Trimethyl-Histone H3 (Lys4)
Includes Trimethyl-Histone H3 (Lys4) ChIP validated Antibody and Primer set including the ChIP-grade antibody and the specific control PCR primers used for chromatin immunoprecipitation of H3K4Me3.
Target Species Human, Mammalia, Mouse
Content And Storage −20°C for one year from date of shipment
Form Purified
Isotype IgG
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For Research Use Only

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