MilliporeSigma Upstate p300, HAT Domain Recombinant Enzyme
Recombinant GST-fusion protein corresponding to amino acids 1066-1707 of human p300.
Manufacturer: MilliporeSigma 14418
DescriptionEP300 encodes the adenovirus E1A-associated cellular p300 transcriptional co-activator protein. p300 is related by sequence to CBP (CREB-binding protein [CREB: cyclic-AMP responsive element binding protein]), and like CBP can stimulate transcription through activation of CREB. This EP300 activity is specifically inhibited by the adenovirus oncoprotein E1A. EP300 has also been identified as a co-activator of HIF1A (hypoxia-inducible factor 1 alpha), and thus plays a role in the stimulation of hypoxia-induced genes such as VEGF.
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|Histone Acetyltransferase Assay (HAT)|
|Expressed in E. coli|
|-20°C for up to 6 months from the date of receipt|
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