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Invitrogen™ Endothelin 1 Monoclonal Antibody (TR.ET.48.5)
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Catalog No. MA3005
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100 μL
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MA3005 100 μL
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Catalog No. MA3005 Supplier Invitrogen™ Supplier No. MA3005
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Description

Mouse Monoclonal Antibody

MA3-005 detects ET-1 from human, sheep, mouse and rat tissues. This antibody shows little cross-reactivity to related peptides and no known cross-reactivity to non-related peptides. MA3-005 has been successfully used in Western blot, flow cytometry, immunofluorescence, immunohistochemistry, immunocytochemistry, and radioimmune assay procedures. Immunohistochemical staining of ET-1 in human corpus cavernosum tissue with MA3-005 results in staining of endothelial cells. Radioimmune assays using MA3-005 can be used to concentrate ET-1 in solution (e.g. serμm/plasma, milk, urine). This antibody is not recommended for human placenta tissue or HepG2 cells in Western blot applications. For immunohistochemistry with MA3-005 formalin-fixed, paraffin-embedded tissue sections has been used. The MA3-005 antigen is purified human endothelin-1. Studies suggest that this antibody binds to an epitope in the region of ET-1 represented by amino acids 8-16.

The protein encoded by this gene is proteolytically processed to release a secreted peptide termed endothelin 1. This peptide is a potent vasoconstrictor and is produced by vascular endothelial cells. Endothelin 1 also can affect the central nervous system. Two transcript variants encoding different isoforms have been found for this gene.
TRUSTED_SUSTAINABILITY

Specifications

Antigen Endothelin 1
Applications Flow Cytometry, Immunohistochemistry (Frozen), Immunohistochemistry (Paraffin), Radioimmune Assays (RIA), Western Blot, Immunocytochemistry
Classification Monoclonal
Clone TR.ET.48.5
Concentration 2.5 mg/mL
Conjugate Unconjugated
Formulation PBS with 0.05% sodium azide
Gene EDN1
Gene Accession No. P05305, P22387, P22388, Q9BG76
Gene Alias ARCND3; Big endothelin 1; Big endothelin-1; Big ET; Big ET 1; Big ET1; BigET; EDN1; endothelin 1; endothelin-1; Et; ET1; ET-1; HDLCQ7; PPET1; ppET-1; preproendothelin; preproendothelin-1; preproET; QME
Gene Symbols EDN1
Host Species Mouse
Immunogen Pure endothelin-1 conjugated to KLH.
Purification Method Affinity chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 13614, 1906, 24323, 443498
Target Species Human, Mouse, Sheep, Rat
Content And Storage -20°C, Avoid Freeze/Thaw Cycles
Product Type Antibody
Form Liquid
Isotype IgG1
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