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Apexbio Technology LLC (-)-epicatechin gallate,5mg CAS# 1257-08-5
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Supplier:  Apexbio Technology LLC B49655

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(-)-epicatechin gallate is a major catechin component in green tea [1]. (-)-epicatechin gallate (ECG) plays an important role in cell growth inhibition, apoptosis and membrane transport system [1]. (-)-epicatechin gallate is a kind of catechin. In HCT-116 cells, ECG activated transcription factor 3 (ATF3), which played a critical role in pro-apoptosis. EGR-1 was involved in ECG-induced ATF3 expression. In HCT-116 cells, ECG (50 µM) increased NAG-1 and ATF3 expression in time- and dose-dependent way [1]. In carcinoma HSC-2 cells, ECG (50 µM) exhibited cytotoxicity with midpoint cytotoxicity (NR50) value of 67 µM. However, in normal HGF-2 fibroblasts, ECG exhibited cytotoxicity at concentrations up to 25 µM with NR50 value of 100 µM. In carcinoma HSC-2 cells, ECG (250 µM) induced nucleosomal DNA fragmentation and apoptosis. ECG (150 µM) significantly increased caspase-3 activity [2]. Other sizes are also available. Please inqury us for quote.

Catalog No. 50-224-0361


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