(-)-Epicatechin gallate, Thermo Scientific Chemicals

Description

A natural product from green tea that induces apoptosis

(-)-Epicatechin gallate is used as an antioxidant investigated as an adjunct treatment of some methyicillin resistant bacteria. Epicatechin gallate binds to the cell membrane in methicillin-resistant Staphylococcus aureus which decreases the fluidity of the bilayer and induces changes in gene expression. One of the catechin isomers and a potent antioxidant that can modulate a wide range of membrane proteins. Its bilayer-modifying potency was tested using gramicidin A (gA) channels as probes. All the catechins alter gA channel function and modify bilayer properties, with a 500-fold range in potency.

This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.

Applications
(-)-Epicatechin gallate is used as an antioxidant investigated as an adjunct treatment of some methyicillin resistant bacteria. Epicatechin gallate binds to the cell membrane in methicillin-resistant Staphylococcus aureus which decreases the fluidity of the bilayer and induces changes in gene expression. One of the catechin isomers and a potent antioxidant that can modulate a wide range of membrane proteins. Its bilayer-modifying potency was tested using gramicidin A (gA) channels as probes. All the catechins alter gA channel function and modify bilayer properties, with a 500-fold range in potency.

Solubility
Soluble in water, acetone, DMSO, methanol.

Notes
Store in cool place. Keep container tightly closed in a dry and well-ventilated place. Recommended storage temperature: 2 - 8°C

Specifications

Chemical Identifiers

• CAS: 1257-08-5
• Molecular Formula: C22H18O10
• Molecular Weight (g/mol): 442.376
• MDL Number: MFCD00075936
• InChI Key: LSHVYAFMTMFKBA-TZIWHRDSSA-N
• Synonym: =--epicatechin gallate, epicatechin gallate, =--epicatechin-3-o-gallate, l-epicatechin gallate, =--epicatechin-3-gallate, =--epicatechingallate, epicatechin monogallate, --epicatechin 3-o-gallate, teatannin, epicatechol, gallate
• PubChem CID: 107905
• ChEBI: CHEBI:70255
• IUPAC Name: [(2R,3R)-2-(3,4-dihydroxyphenyl)-5,7-dihydroxy-3,4-dihydro-2H-chromen-3-yl] 3,4,5-trihydroxybenzoate
• SMILES: C1C(C(OC2=CC(=CC(=C21)O)O)C3=CC(=C(C=C3)O)O)OC(=O)C4=CC(=C(C(=C4)O)O)O

• Color: White
• Quantity: 10 mg
• Solubility Information: Soluble in water,acetone,DMSO,methanol.
• Formula Weight: 442.37
• Physical Form: Powder
• Chemical Name or Material: (-)-Epicatechin gallate

Safety and Handling

RTECSNumber	DH9030000
TSCA	No
Recommended Storage	Keep cold

SDS

RUO – Research Use Only