(-)-Epigallocatechin Gallate, MP Biomedicals™

Description

Inhibits telomerase and DNA methyltransferase. (-)-Epigallocatechin Gallate, MP Biomedicals is a polyphenolic, tumor-inhibiting constituent of green tea. ECGC is an antioxidant polyphenol flavonoid that inhibits cellular oxidation of low density lipoprote

A natural component of green tea with a variety of biological functions:

• Bocks the activation of EGF receptors and HER-2 receptors
• Inhibits fatty acid synthase and glutamate dehydrogenase activity
• Inhibits the peroxynitrite-induced formation of the oxidative injury markers 8-hydroxy-2-deoxy guanosine and 3-nitrotyrosine, apoptosis in human prostate cancer cells
• Selectively inhibits activation of JNK/SAPK signaling pathway and suppresses proliferation of vascular smooth muscle cells
• Shows growth inhibitory effects on tumor cells but not their normal counterparts
• Inhibits telomerase, a fast-binding and reversible fatty acid synthase inhibitor
• Inhibits PMA-induced skin thickening
• Inhibits activation of interleukin-1a mRNA and protein expression
• Inhibits nitric oxide synthase (iNOS) gene expression
• At μM concentrations, inhibits VEGF-induced tyrosine phosphorylation

Specifications

Chemical Identifiers

• CAS: 989-51-5
• Molecular Formula: C22H18O11
• Molecular Weight (g/mol): 458.375
• InChI Key: WMBWREPUVVBILR-WIYYLYMNSA-N
• Synonym: =--epigallocatechin gallate, egcg, epigallocatechin gallate, epigallocatechin 3-gallate, tea catechin, epigallocatechin-3-gallate, =--epigallocatechin-3-o-gallate, teavigo, =--epigallocatechol gallate, epigallocatechin-3-monogallate
• PubChem CID: 65064
• ChEBI: CHEBI:4806
• IUPAC Name: [(2R,3R)-5,7-dihydroxy-2-(3,4,5-trihydroxyphenyl)-3,4-dihydro-2H-chromen-3-yl] 3,4,5-trihydroxybenzoate
• SMILES: C1C(C(OC2=CC(=CC(=C21)O)O)C3=CC(=C(C(=C3)O)O)O)OC(=O)C4=CC(=C(C(=C4)O)O)O

• Melting Point: 218°C (literature)
• Quantity: 50 mg
• Solubility Information: Soluble in water (5mg/mL, clear, faint pink colored solution).
• Optical Rotation: −185° ± 2° (ethanol) (Lit.)
• Formula Weight: 458.4g/mol
• Percent Purity: ≥95%
• Physical Form: Powder

Safety and Handling

Recommended Storage

Store at 4°C.