Invitrogen™ Epstein Barr Virus Early Antigen Monoclonal Antibody (1108-1)

Mouse Monoclonal Antibody

Supplier:  Invitrogen™ MA135751

Catalog No. 01-672-057

Description

1108-1 Recognizes a 55-50 kDa polypeptide associated with the early antigen of Epstein-Barr virus (EBV). p55 Has beenshown to be a phosphoprotein and p55-50 has strong DNA-binding activity preferentially to single-stranded DNA. Epstein-Barr virus is the causitive agent of infectious mononucleosis and is associated with two human neoplasms, Burkitt's lymphoma and nasopharyngeal carcinoma. Several EBV-related antigens associated with early or late functions of the viral genome have been identified. The early antigen may be virally or chemically induced in EBV infected cells and is the first detectable marker of EBV infection in human cells.

Epstein-Barr virus (EBV) is a human herpes virus, which is associated with conditions such as Hodgkin's disease and Burkitt's Lymphoma and is the causative agent in mononucleosis in adolescents. EBV latently infects B lymphocytes. Infected B cells express EBV nuclear antigens and latent proteins LMP1, LMP2A and LMP2B. LMP2A forms aggregates in the plasma membranes of B lymphocytes, where it functions as a negative regulator of the Src and Syk protein tyrosine kinases. Studies show that LMP2A blocks B-cell receptor (BCR) signal transduction in EBV immortalized B cells in vitro and may play an important role in maintaining a latent EBV infection within the peripheral blood B cells of infected individuals.EBNA-1 is the only viral protein consistently expressed in all malignancies associated with EBV.

Specifications

• Antigen: Epstein Barr Virus Early Antigen
• Classification: Monoclonal
• Concentration: 0.1 mg/mL
• Formulation: PBS with 0.02% sodium azide
• Host Species: Mouse
• Purification Method: Purified
• Regulatory Status: RUO
• Target Species: Virus
• Product Type: Antibody
• Isotype: IgG1

• Applications: Flow Cytometry, Immunohistochemistry (Frozen), Immunohistochemistry (Paraffin), Immunoprecipitation
• Clone: 1108-1
• Conjugate: Unconjugated
• Gene Alias: EBV; EBV EA; EBV early
• Immunogen: EBV early antigens.
• Quantity: 100 μg
• Primary or Secondary: Primary
• Content And Storage: 4°C
• Form: Liquid