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Invitrogen™ Epstein Barr Virus LMP2A Monoclonal Antibody (15F9)
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Catalog No. PIMA181921
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250 μg
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Catalog No. Quantity
PIMA181921 250 μg
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Catalog No. PIMA181921 Supplier Invitrogen™ Supplier No. MA181921
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Description

Rat Monoclonal Antibody

Heat-mediated antigen retrieval using a sodium citrate buffer (pH 6.0) is recommended for the staining of paraffin sections. Rat anti Epstein-Barr Virus LMP2A antibody, clone 15F9 recognizes latent membrane protein 2A (LMP2A) of Epstein-Barr virus (EBV).

Epstein-Barr virus (EBV) is a human herpes virus, which is associated with conditions such as Hodgkin's disease and Burkitt's Lymphoma and is the causative agent in mononucleosis in adolescents. EBV latently infects B lymphocytes. Infected B cells express EBV nuclear antigens and latent proteins LMP1, LMP2A and LMP2B. LMP2A forms aggregates in the plasma membranes of B lymphocytes, where it functions as a negative regulator of the Src and Syk protein tyrosine kinases. Studies show that LMP2A blocks B-cell receptor (BCR) signal transduction in EBV immortalized B cells in vitro and may play an important role in maintaining a latent EBV infection within the peripheral blood B cells of infected individuals.EBNA-1 is the only viral protein consistently expressed in all malignancies associated with EBV.
TRUSTED_SUSTAINABILITY

Specifications

Antigen Epstein Barr Virus LMP2A
Applications Immunohistochemistry (Paraffin), Western Blot
Classification Monoclonal
Clone 15F9
Concentration 1 mg/mL
Conjugate Unconjugated
Formulation PBS with 0.09% sodium azide; pH 7.4
Gene Alias EBV
Host Species Rat
Immunogen Bacterial TrpE-LMP2A fusion protein.
Purification Method Protein G
Quantity 250 μg
Regulatory Status RUO
Primary or Secondary Primary
Target Species Virus
Content And Storage Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Product Type Antibody
Form Liquid
Isotype IgG1
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