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Invitrogen™ Epstein Barr Virus Nuclear Antigen 1 Monoclonal Antibody (E1-2.5)
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Catalog No. 01676002
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100 μg
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Catalog No. Quantity
01-676-002 100 μg
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Catalog No. 01-676-002 Supplier Invitrogen™ Supplier No. MA119238
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Description

Mouse Monoclonal Antibody

This antibody recognizes repetitive Gly-Ala region of the Epstein-Barr virus (EBV) nuclear antigen 1 (EBNA-1). EBNA-1 is the only viral protein consistently expressed in all malignancies associated with EBV.

Epstein-Barr virus (EBV) is a human herpes virus, which is associated with conditions such as Hodgkin's disease and Burkitt's Lymphoma and is the causative agent in mononucleosis in adolescents. EBV latently infects B lymphocytes. Infected B cells express EBV nuclear antigens and latent proteins LMP1, LMP2A and LMP2B. LMP2A forms aggregates in the plasma membranes of B lymphocytes, where it functions as a negative regulator of the Src and Syk protein tyrosine kinases. Studies show that LMP2A blocks B-cell receptor (BCR) signal transduction in EBV immortalized B cells in vitro and may play an important role in maintaining a latent EBV infection within the peripheral blood B cells of infected individuals.EBNA-1 is the only viral protein consistently expressed in all malignancies associated with EBV.
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Specifications

Antigen Epstein Barr Virus Nuclear Antigen 1
Applications ELISA, Immunohistochemistry (Paraffin), Immunocytochemistry
Classification Monoclonal
Clone E1-2.5
Concentration 1 mg/mL
Conjugate Unconjugated
Formulation PBS with 15mM sodium azide; pH 7.4
Gene Alias EBNA-1
Host Species Mouse
Immunogen Epstein-Baar nuclear antigen 1.
Purification Method Protein A
Quantity 100 μg
Regulatory Status RUO
Primary or Secondary Primary
Target Species Virus
Content And Storage 4°C, do not freeze
Product Type Antibody
Form Liquid
Isotype IgG2b
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