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Invitrogen™ Epstein Barr Virus Nuclear Antigen 1 Monoclonal Antibody (EBS-I-024)
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Catalog No. PIMA533321
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100 μg
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Catalog No. Quantity
PIMA533321 100 μg
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Catalog No. PIMA533321 Supplier Invitrogen™ Supplier No. MA533321
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Description

Mouse Monoclonal Antibody

EBS-I-024 reacts with a conserved domain on EBNA1 (AA 430-442), present in all EBV isolates. EBNA1 is expressed in all viral latency stages in vitro and in vivo.

Epstein-Barr virus (EBV) is a human herpes virus, which is associated with conditions such as Hodgkin's disease and Burkitt's Lymphoma and is the causative agent in mononucleosis in adolescents. EBV latently infects B lymphocytes. Infected B cells express EBV nuclear antigens and latent proteins LMP1, LMP2A and LMP2B. LMP2A forms aggregates in the plasma membranes of B lymphocytes, where it functions as a negative regulator of the Src and Syk protein tyrosine kinases. Studies show that LMP2A blocks B-cell receptor (BCR) signal transduction in EBV immortalized B cells in vitro and may play an important role in maintaining a latent EBV infection within the peripheral blood B cells of infected individuals.EBNA-1 is the only viral protein consistently expressed in all malignancies associated with EBV.
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Specifications

Antigen Epstein Barr Virus Nuclear Antigen 1
Applications ELISA, Immunohistochemistry (Paraffin), Western Blot
Classification Monoclonal
Clone EBS-I-024
Concentration 100 μg/mL
Conjugate Unconjugated
Formulation PBS with 0.02% sodium azide
Gene Alias EBNA-1
Host Species Mouse
Immunogen EBNA1 synthetic peptide (AA-424-460).
Purification Method Affinity chromatography
Quantity 100 μg
Regulatory Status RUO
Primary or Secondary Primary
Target Species Virus
Content And Storage 4°C, do not freeze
Product Type Antibody
Form Liquid
Isotype IgG1 κ
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