Invitrogen™ Epstein Barr Virus Nuclear Antigen 1 Monoclonal Antibody (EBS-I-024)

Mouse Monoclonal Antibody

Supplier:  Invitrogen™ MA533321

Catalog No. PIMA533321

Description

EBS-I-024 reacts with a conserved domain on EBNA1 (AA 430-442), present in all EBV isolates. EBNA1 is expressed in all viral latency stages in vitro and in vivo.

Epstein-Barr virus (EBV) is a human herpes virus, which is associated with conditions such as Hodgkin's disease and Burkitt's Lymphoma and is the causative agent in mononucleosis in adolescents. EBV latently infects B lymphocytes. Infected B cells express EBV nuclear antigens and latent proteins LMP1, LMP2A and LMP2B. LMP2A forms aggregates in the plasma membranes of B lymphocytes, where it functions as a negative regulator of the Src and Syk protein tyrosine kinases. Studies show that LMP2A blocks B-cell receptor (BCR) signal transduction in EBV immortalized B cells in vitro and may play an important role in maintaining a latent EBV infection within the peripheral blood B cells of infected individuals.EBNA-1 is the only viral protein consistently expressed in all malignancies associated with EBV.

Specifications

• Antigen: Epstein Barr Virus Nuclear Antigen 1
• Classification: Monoclonal
• Concentration: 100 μg/mL
• Formulation: PBS with 0.02% sodium azide
• Host Species: Mouse
• Purification Method: Affinity chromatography
• Regulatory Status: RUO
• Target Species: Virus
• Product Type: Antibody
• Isotype: IgG1 κ

• Applications: ELISA, Immunohistochemistry (Paraffin), Western Blot
• Clone: EBS-I-024
• Conjugate: Unconjugated
• Gene Alias: EBNA-1
• Immunogen: EBNA1 synthetic peptide (AA-424-460).
• Quantity: 100 μg
• Primary or Secondary: Primary
• Content And Storage: 4°C, do not freeze
• Form: Liquid