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ErbB2 (HER-2) Monoclonal Antibody (MJD2), eBioscience™, Invitrogen™
Mouse Monoclonal Antibody
$546.00
Specifications
Antigen | ErbB2 (HER-2) |
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Clone | MJD2 |
Concentration | 0.5 mg/mL |
Classification | Monoclonal |
Conjugate | Unconjugated |
Catalog Number | Mfr. No. | Quantity | Price | Quantity & Availability | |||||
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Catalog Number | Mfr. No. | Quantity | Price | Quantity & Availability | |||||
50-112-2828
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Invitrogen™
14975782 |
100 μg |
Each of 1 for $546.00
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Description
Description: This MJD2 monoclonal antibody reacts with HER-2, the product of the ErbB2 gene and a member of the human epidermal growth factor receptor (EGFR) family. HER-2 is a 185 kDa transmembrane receptor with an extracellular binding domain and an intracellular tyrosine kinase domain. Activation of HER-2 occurs following formation of homodimers or heterodimers with ligand-bound EGFR family members, HER3 or HER4. Overexpression of HER-2 results in auto-phosphorylation and increased proliferation and invasiveness and is associated with subsets of multiple cancer types such as breast, ovarian, cervical, uterine, and gastric. The use of HER-2 targeted agents has been used extensively to treat HER-2-positive breast cancer, but a recent study found that these agents can also block the proliferation of breast cancer stem cells found in HER-2-negative patients and suggests the importance of HER-2 as a target for multiple types of breast cancer. The MJD2 antibody recognizes the extracellular domain of HER-2 but at an epitope distinct from that recognized by the 4D5 (Herceptin) and SP3 monoclonal antibodies. Applications Reported: This MJD2 antibody has been reported for use in western blotting, immunohistochemical staining of formalin-fixed paraffin embedded tissue sections, microscopy, and immunocytochemistry.
ErbB2 (HER2) is a receptor tyrosine kinase that is overexpressed in some breast tumors. Herceptin, used in treatment of metastatic Her2-positive cancer, is monoclonal antibody targeting this kinase.Specifications
ErbB2 (HER-2) | |
0.5 mg/mL | |
Unconjugated | |
Mouse | |
Human | |
2064 | |
IgG1 κ | |
Affinity chromatography | |
Antibody |
MJD2 | |
Monoclonal | |
Liquid | |
RUO | |
P04626 | |
ERBB2 | |
Primary | |
4°C | |
ERBB2 |
For Research Use Only.
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