ERBB2 Monoclonal Antibody (3G11-14), TrueMAB™, OriGene

Catalog No.	Quantity
50-168-2307	100 μL

Catalog No. 50-168-2307 Supplier OriGene Supplier No. TA808699

Description

Mouse Monoclonal Antibody

ErbB2 (Her2/neu) is a 185 kDa transmembrane receptor tyrosine kinase from the EGFR (epidermal growth factor receptor) family that regulates biological responses such as cell growth, differentiation, and tissue development. ErbB2 has no ligand binding domain of its own and cannot bind growth factors. However, ErbB2 does bind tightly to other ligand-bound EGF receptor family members to form a heterodimer, stabilizing ligand binding and enhancing kinase-mediated activation of downstream signaling pathways, such as those involving mitogen-activated protein kinase and phosphatidylinositol-3 kinase. Autophosphorylation of tyrosine 1139 on ErbB2 allows binding of Grb2 and the Src SH2 domain, which allows activation of the Ras, Raf, ERK1/2 and JAK/STAT signaling pathways, respectively. Alternative splicing of ErbB2 results in several transcript variants, some encoding different isoforms and others that have not been fully characterized. In humans, the gene encoding ERBB2 is present on chromosome 17. Amplification and/or overexpression of the ErbB2 gene has been reported in ovarian tumors, breast, lung and skin cancer.

Specifications

• Antigen: ERBB2
• Applications: Flow Cytometry
• Classification: Monoclonal
• Clone: 3G11-14
• Concentration: 0.5 mg/mL
• Conjugate: Unconjugated
• Formulation: PBS with 1% BSA, 50% glycerol and 0.02% sodium azide
• Gene: ERBB2
• Gene Accession No.: P04626
• Gene Alias: CD340, HER-2, HER-2/neu, HER2, MLN 19, NEU, NGL, TKR1
• Gene Symbols: ERBB2
• Host Species: Mouse
• Immunogen: HER2 extracellular domain (aa 23-652) expressed in HEK293 cells with a C-terminal DDK tag
• Purification Method: Affinity Chromatography
• Quantity: 100 μL
• Regulatory Status: RUO
• Primary or Secondary: Primary
• Gene ID (Entrez): 2064
• Target Species: Human
• Content And Storage: -20° C, Avoid Freeze/Thaw Cycles
• Product Type: Antibody
• Form: Liquid
• Isotype: IgG1 κ