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Invitrogen™ ERCC1 Monoclonal Antibody (CL1284)
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Catalog No. PIMA531359
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100 μL
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PIMA531359 100 μL
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Catalog No. PIMA531359 Supplier Invitrogen™ Supplier No. MA531359
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Description

Mouse Monoclonal Antibody

Immunogen sequence: LADCTLILAW SPEEAGRYLE TYKAYEQKPA DLLMEKLEQD FVSRVTECLT TVKSVNKTDS QTLLTTFGSL EQLIAASRED LALCPGLGPQ KARRLFDVLH EPFLKVP Highest antigen sequence indentity to the following orthologs: Mouse - 92%, Rat - 93%.

ERCC1 is a non-catalytic component of a structure-specific DNA repair endonuclease responsible for the 5'-incision during DNA repair. It is responsible, in conjunction with SLX4, for the first step in the repair of interstrand cross-links (ICL). It participates in the processing of anaphase bridge-generating DNA structures, which consist in incompletely processed DNA lesions arising during S or G2 phase, and can result in cytokinesis failure. ERCC1 is also required for homology-directed repair (HDR) of DNA double-strand breaks, in conjunction with SLX4. (Uniprot).
TRUSTED_SUSTAINABILITY

Specifications

Antigen ERCC1
Applications Immunohistochemistry (Paraffin), Western Blot
Classification Monoclonal
Clone CL1284
Concentration 0.7 mg/mL
Conjugate Unconjugated
Formulation PBS with 40% glycerol and 0.02% sodium azide; pH 7.2
Gene ERCC1
Gene Accession No. P07992
Gene Alias COFS4; DNA excision repair protein ERCC-1; ERCC excision repair 1, endonuclease non-catalytic subunit; Ercc1; Ercc-1; excision repair cross-complementation group 1; excision repair cross-complementing 1; excision repair cross-complementing rodent repair deficiency, complementation group 1; excision repair cross-complementing rodent repair deficiency, complementation group 1 (includes overlapping antisense sequence); hypothetical protein LOC405807; RAD10; UV20; zgc:77511
Gene Symbols ERCC1
Host Species Mouse
Immunogen Recombinant protein fragment of Human ERCC1 (Product #RP-108164)
Purification Method Protein A
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 2067
Target Species Human
Content And Storage Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Product Type Antibody
Form Liquid
Isotype IgG1
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