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ESR1 Monoclonal Antibody (OTI5E11), TrueMAB™, OriGene
SDP

Catalog No. p-200018234
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100 μL
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Catalog No. Quantity
50-168-2569 100 μL
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Catalog No. 50-168-2569 Supplier OriGene Supplier No. TA809106
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Description

Mouse Monoclonal Antibody

Estrogen Receptors (ER) are members of the steroid/thyroid hormone receptor superfamily of nuclear receptors. The estrogen receptor is a ligand-activated transcription factor, that when bound to estrogen hormone, induces a conformational change that allows dimerization and binding to estrogen response elements (ERE) in DNA. When bound to EREs, ER can positively or negatively regulate gene transcription through the recruitment of coactivator or corepressor proteins. There are two different forms of the estrogen receptor, alpha and beta, encoded by separate genes (ESR1 and ESR2, respectively). Due to alternative RNA splicing, at least 4 estrogen receptor-alpha isoforms are known to exist (Isoform 1 (66 kDa), Isoform 2 (53 kDa), Isoform 3 (47 kDa), Isoform 4 (35 kDa)). Estrogen receptors are widely expressed in different tissue types and are essential for sexual development and reproductive function. They also play a role in other tissues such as bone. Estrogen receptors are involved in pathological processes including breast cancer, endometrial cancer, and osteoporosis.

Specifications

Antigen ESR1
Applications Immunohistochemistry (Paraffin), Western Blot
Classification Monoclonal
Clone OTI5E11
Conjugate Unconjugated
Formulation PBS with 1% BSA, 50% glycerol and 0.02% sodium azide
Gene ESR1
Gene Accession No. P03372
Gene Alias ER, ESR, ESRA, ESTRR, Era, NR3A1
Gene Symbols ESR1
Host Species Mouse
Immunogen Human recombit protein fragment corresponding to amino acids 1-310 of human ESR1 produced in E.coli.
Purification Method Affinity Chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 2099, 403640
Target Species Canine, Human
Content And Storage -20° C, Avoid Freeze/Thaw Cycles
Product Type Antibody
Form Liquid
Isotype IgG2a
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