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Estrone, 99+%, Thermo Scientific Chemicals
Description
This Thermo Scientific Chemicals brand product was originally part of the Acros Organics product portfolio. Some documentation and label information may refer to the legacy brand. The original Acros Organics product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.
General Description
• Estrone is an aromatized C18 steroid considered one of the major mammalian estrogen and a sex hormone. It shows antineoplastic and bone density conservative activities.
• This compound can interact with estrogen receptors in target tissues to produce similar effects to estradiol. Hormone-bound estrogen receptors dimerize, translocate to the nucleus of cells and bind to estrogen response elements (ERE) of genes. Binding to ERE alters the transcription rate of affected genes.
Applications
• Estrone has the ability to increase the hepatic synthesis of sex hormone binding globulin (SHBG), thyroid-binding globulin (TBG), and other serum proteins.
• It can suppress the release of follicle-stimulating hormone and luteinizing hormone.
• This compound can be produced from androstenedione or testosterone via estradiol. In vivo, it can be generated mainly in the ovaries, placenta, and peripheral tissues (especially adipose tissue) through conversion of androstenedione. It may be metabolized to 16-α-hydroxyestrone, which may be reduced to estriol by estradiol dehydrogenase.
• It has been used as medium supplement for hormone-based degranulation studies of natural killer cells.
• It is used as medium component for monitoring fatty acid synthase activity in breast adenocarcinoma cell lines.
Specifications
Melting Point | 258.0°C to 261.0°C |
Color | White |
Loss on Drying | 0.5% max. (105°C, 3 hrs) |
Infrared Spectrum | Authentic |
Assay Percent Range | 99% min. (on dried substance) (HPLC) |
Packaging | Glass bottle |
Quantity | 1 g |
Merck Index | 15,3763 |
Specific Rotation Condition | + 158.00 (20.00°C c=1,dioxane) |
Specific Rotation | + 158.00 |
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Safety and Handling
Hazard Category | GHS Signal Word: Danger |
Hazard Statement | GHS H Statement: Harmful if swallowed. Suspected of causing cancer. Harmful in contact with skin. May cause an allergic skin reaction. Harmful if inhaled. May cause allergy or asthma symptoms or breathing difficulties if inhaled. Suspected of damaging fertility. |
Precautionary Statement | GHS P Statement: Wear protective gloves/protective clothing/eye protection/face protection. Avoid breathing dust/fume/gas/mist/vapors/spray. IF INHALED: If breathing is difficult, remove to fresh air and keep at rest in a position comfortable for breathing. If experiencing respiratory symptoms: Call a POISON CENTER or doctor/physician. Wear eye protection/face protection. Use personal protective equipment as required. IF ON SKIN: Wash with plenty of soap and water. IF SWALLOWED: Call a POISON CENTER or doctor/physician if you feel unwell. IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for breathing. WARNING: The information provided on this web site was developed in compliance with European Union (EU) regulations and is correct to the best of our knowledge, information and belief at the date of its publication. The information given is designed only as a guide for safe handling and use. It is |
EINECSNumber | 200-164-5 |
RUO – Research Use Only
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