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Invitrogen™ ETS1 Polyclonal Antibody
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Catalog No. PIPA590605
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100 μL
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PIPA590605 100 μL
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Catalog No. PIPA590605 Supplier Invitrogen™ Supplier No. PA590605
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Description

Rabbit Polyclonal Antibody

Immunogen sequence: LELLTDKSCQ SFISWTGDGW EFKLSDPDEV ARRWGKRKNK PKMNYEKLSR GLRYYYDKNI IHKTAGKRYV YRFVCDLQSL LGYTPEELHA MLDVKPDADE Positive Samples: Mouse thymus; Cellular Location: Cytoplasm, Nucleus.

ETS1 (c-Ets-1; v-ets erythroblastosis virus E26 oncogene homlog 1 (avian); ETS-1; EWSR2; p54), a 441 A. A protein, is a member of DNA-binding ETS protein family. It is a multifunctional protein consisting of an N-terminal pointed domain, a central transactivation domain and 2 auto inhibitory domains flanked on both sides of conserved C-terminal Ets domain. It interacts with factors including PEBP2alphaA, p300/CBP and mediates transactivation of Osteopontin, Presenilin-1, Stromelysin and Collagenase. It is activated by Ras/MAPK signaling and its expression is up-regulated in resting T-cells. Its activity is modulated by various factors including AP-1, Sp-1, c-myb and MafB. Sp100 activates ETS1 in nuclear bodies. It interacts with EAP1/Daxx and causes repression of MMP1 and BCL2 transactivation. It interacts with STAT6 and modulates Socs-1 expression induced by IL-4. It interacts with GATA3 and positively regulates Tax-1 dependent IL-5 expression.
TRUSTED_SUSTAINABILITY

Specifications

Antigen ETS1
Applications ELISA, Western Blot, Immunocytochemistry
Classification Polyclonal
Concentration 1.98 mg/mL
Conjugate Unconjugated
Formulation PBS with 50% glycerol and 0.01% thimerosal; pH 7.3
Gene ETS1
Gene Accession No. P14921, P27577, P41156
Gene Alias AI196000; AI448617; Avian erythroblastosis virus E26 (v-ets) oncogene homolog-1; avian erythroblastosis virus E26 oncogene 1; c-ets protein; c-ets1; c-ets-1; c-ets-1 oncogene; c-ets-1 protein; c-ets-alpha; c-ets-beta; D230050P06; E26 avian leukemia oncogene 1, 5' domain; Ets avian erythroblastosis virus E2 oncogene homolog 1 (tumor progression locus 1); ets protein; ETS proto-oncogene 1, transcription factor; Ets1; ETS-1; ETS-1A; ETS-1B; Ets-1Delta(III-VI); Etsoncb; EWSR2; FLJ10768; oncoprotein; p54; p54 transcription factor; protein C-ets-1; TNFAIP3 interacting protein 1; TNIP1; Tpl1; transforming protein p54/c-ets-1; transforming protein p68/c-ets-1; tumor progression locus 1; unnamed protein product; v-ets avian erythroblastosis virus E2 oncogene homolog 1; v-ets avian erythroblastosis virus E26 oncogene homolog 1; v-ets erythroblastosis virus E26 oncogene homolog 1; virion-associated nuclear-shuttling protein
Gene Symbols ETS1
Host Species Rabbit
Immunogen A synthetic peptide corresponding to a sequence within amino acids 342-441 of human ETS1 (NP_0052291).
Purification Method Affinity chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 2113, 23871, 24356
Target Species Human, Mouse, Rat
Content And Storage -20°C, Avoid Freeze/Thaw Cycles
Product Type Antibody
Form Liquid
Isotype IgG
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WARNING: Cancer - www.P65Warnings.ca.gov
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