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Invitrogen™ EWSR1 Monoclonal Antibody (5H7)
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Catalog No. PIMA547689
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100 μL
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PIMA547689 100 μL
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Catalog No. PIMA547689 Supplier Invitrogen™ Supplier No. MA547689
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Description

Mouse Monoclonal Antibody

Specific for endogenous levels of the ~85 kDa EWS protein.

This gene encodes a multifunctional protein that is involved in various cellular processes, including gene expression, cell signaling, and RNA processing and transport. The protein includes an N-terminal transcriptional activation domain and a C-terminal RNA-binding domain. Chromosomal translocations between this gene and various genes encoding transcription factors result in the production of chimeric proteins that are involved in tumorigenesis. These chimeric proteins usually consist of the N-terminal transcriptional activation domain of this protein fused to the C-terminal DNA-binding domain of the transcription factor protein. Mutations in this gene, specifically a ttranslocation, are known to cause Ewing sarcoma as well as neuroectodermal and various other tumors. Alternative splicing of this gene results in multiple transcript variants. Related pseudogenes have been identified on chromosomes 1 and 14.
TRUSTED_SUSTAINABILITY

Specifications

Antigen EWSR1
Applications Immunohistochemistry (Frozen), Western Blot, Immunocytochemistry
Classification Monoclonal
Clone 5H7
Concentration 1 mg/mL
Conjugate Unconjugated
Formulation PBS with 50% glycerol and 5 mM sodium azide
Gene EWSR1
Gene Accession No. Q01844, Q61545
Gene Alias AC002059.7; bK984G1.4; Ewing sarcoma breakpoint region 1; Ewing sarcoma breakpoint region 1 protein; Ewing sarcoma homolog; Ewings sarcoma EWS-Fli1 (type 1) oncogene; Ews; EWS oncogene; EWS RNA binding protein 1; EWS RNA-binding protein 1; EWS RNA-binding protein variant 6; EWS-FLI1; Ewsh; EWSR1; RNA-binding protein EWS
Gene Symbols EWSR1
Host Species Mouse
Immunogen Full length recombinant human EWS expressed in and purified from E. coli.
Purification Method Protein G
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 14030, 2130, 609786
Target Species Human, Mouse, Canine
Content And Storage -20°C, Avoid Freeze/Thaw Cycles
Product Type Antibody
Form Liquid
Isotype IgG2b
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