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  7. EX 527, Tocris Bioscience™

EX 527, Tocris Bioscience™

Catalog No. 27801
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Quantity:
1 mg
10 mg
50 mg
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This item is not returnable. View return policy

Description

Selective SIRT1 inhibitor

EX 527 is a selective inhibitor of SIRT1 that does not inhibit histone deacetylase (HDAC) or other sirtuin deacetylase family members (IC50 values are 98, 19600, 48700, > 100000 and > 100000 nM for SIRT1, SIRT2, SIRT3, HDAC and NADase respectively). In an animal model of Huntington's disease, EX 527 rescues neuronal degeneration, extends lifespan, reduces huntingtin inclusions and prevents ventricular enlargement. EX 527 enhances p53 acetylation in response to DNA damaging agents. Orally bioavailable and brain penetrant.

Chemical Identifiers

CAS 49843-98-3
Molecular Formula C13H13ClN2O
Molecular Weight (g/mol) 248.71
InChI Key FUZYTVDVLBBXDL-UHFFFAOYSA-N
Synonym selisistat, sirt1 inhibitor iii, 1h-carbazole-1-carboxamide, 6-chloro-2,3,4,9-tetrahydro, 6-chloro-2,3,4,9-tetrahydro-1h-carbazole-1-carboxamide, racemic, selisistat inn, 6-chloro-1,2,3,4,9-pentahydro-4ah-carbazolecarboxamide, ex-527 selisistat, ex 527 selisistat, d0e3lp, cambridge id 6859180
PubChem CID 5113032
IUPAC Name 6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide
SMILES C1CC(C2=C(C1)C3=C(N2)C=CC(=C3)Cl)C(=O)N

Specifications

Quantity 1 mg
Formula Weight 248.71
Percent Purity >98%
Chemical Name or Material EX 527

Safety and Handling

Recommended Storage Store at +4°C
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