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  5. Tocris Bioscience™ EX 527

Tocris Bioscience™ EX 527
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Catalog No. 278050
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Quantity:
1 mg
10 mg
50 mg
Catalog No. Quantity
27-805-0 50 mg
27-801 1 mg
27-801-0 10 mg
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Catalog No. 27-805-0

Supplier: Tocris Bioscience™ 2780/50

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Description

Selective SIRT1 inhibitor

EX 527 is a selective inhibitor of SIRT1 that does not inhibit histone deacetylase (HDAC) or other sirtuin deacetylase family members (IC50 values are 98, 19600, 48700, > 100000 and > 100000 nM for SIRT1, SIRT2, SIRT3, HDAC and NADase respectively). In an animal model of Huntington's disease, EX 527 rescues neuronal degeneration, extends lifespan, reduces huntingtin inclusions and prevents ventricular enlargement. EX 527 enhances p53 acetylation in response to DNA damaging agents. Orally bioavailable and brain penetrant.

Chemical Identifiers

CAS 49843-98-3
Molecular Formula C13H13ClN2O

Specifications

Quantity 50 mg
Formula Weight 248.71
Purity >98%
Molecular Weight (g/mol) 248.71
Chemical Name or Material EX 527

Safety and Handling

Recommended Storage Store at +4°C
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