Invitrogen™ Factor VIII Polyclonal Antibody

Sheep Polyclonal Antibody

Supplier:  Invitrogen™ PA143045

Catalog No. PA143045

Description

PA1-43045 detects Factor VIII in human samples. PA1-43045 has successfully been used in Western blot and ELISA applications. PA1-43045 was derived from human factor VIII. The molecular weight of PA1-43045 is 150 kDa.

This gene encodes coagulation factor VIII, which participates in the intrinsic pathway of blood coagulation; factor VIII is a cofactor for factor IXa which, in the presence of Ca+2 and phospholipids, converts factor X to the activated form Xa. This gene produces two alternatively spliced transcripts. Transcript variant 1 encodes a large glycoprotein, isoform a, which circulates in plasma and associates with von Willebrand factor in a noncovalent complex. This protein undergoes multiple cleavage events. Transcript variant 2 encodes a putative small protein, isoform b, which consists primarily of the phospholipid binding domain of factor VIIIc. This binding domain is essential for coagulant activity. Defects in this gene results in hemophilia A, a common recessive X-linked coagulation disorder.

Specifications

• Antigen: Factor VIII
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: F8
• Gene Alias: AHF; Antihemophilic factor; CF8; Cf-8; coagulation factor VIII; coagulation factor VIII A1 domain; coagulation factor VIII C2 domain; coagulation factor VIII, procoagulant component; coagulation factor VIII, procoagulant component (hemophilia A); coagulation factor VIIIc; DXS1253E; F8; F8B; F8C; Factor 8; Factor VIII; Factor VIII B chain; factor VIII F8B; factor VIII precursor; Factor VIIIa heavy chain, 200 kDa isoform; Factor VIIIa heavy chain, 92 kDa isoform; Factor VIIIa light chain; factor8; FVIII; HEMA; Procoagulant component; RP11-115M6.7
• Host Species: Sheep
• Purification Method: SDS-PAGE
• Regulatory Status: RUO
• Gene ID (Entrez): 2157
• Content And Storage: -20°C, Avoid Freeze/Thaw Cycles
• Form: Liquid

• Applications: Inhibition Assays, Western Blot
• Concentration: 13.8 mg/mL
• Formulation: 50% water with 50% glycerol and no preservative
• Gene Accession No.: P00451
• Gene Symbols: F8
• Immunogen: Human Factor VIII.
• Quantity: 1 mg
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG