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Invitrogen™ Human Factor XI Native Protein

Catalog No. PIRP43075
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Quantity:
50 μg

Description

Native Protein

RP-43075 contains native human Factor XI protein. RP-43075 may be used as a positive control in many immunological assays. The product is of human blood/plasma origin. Although the starting material was tested prior to initiation of the manufacturing process, and was found negative or nonreactive for anti-HIV-1/2, HIV-1 antigen(s), HBsAg, STS, anti-HCV, anti-HBcore and anti-HTLV I & II, extreme caution should be used when handling this material as there is a margin of error in all tests. This product is to be used for IN VITRO research purposes only, and is not intended for clinical or diagnostic use!

This gene encodes coagulation factor XI of the blood coagulation cascade. This protein is present in plasma as a zymogen, which is a unique plasma coagulation enzyme because it exists as a homodimer consisting of two identical polypeptide chains linked by disulfide bonds. During activation of the plasma factor XI, an internal peptide bond is cleaved by factor XIIa (or XII) in each of the two chains, resulting in activated factor XIa, a serine protease composed of two heavy and two light chains held together by disulfide bonds. This activated plasma factor XI triggers the middle phase of the intrisic pathway of blood coagulation by activating factor IX. Defects in this factor lead to Rosenthal syndrome, a blood coagulation abnormality.
TRUSTED_SUSTAINABILITY

Specifications

Accession Number P03951
Concentration 7.0 mg/mL
For Use With (Application) Control
Formulation 50% water with 50% glycerol and no preservative
Gene ID (Entrez) 2160
Molecular Weight (g/mol) 160 kDa
Name Human Factor XI
Quantity 50 μg
Source Human
Regulatory Status RUO
Gene Alias 1600027G01Rik; AI503996; Cf11; Coagulation factor XI; Coagulation factor XIa heavy chain; Coagulation factor XIa light chain; F11; FXI; LRRGT00086; plasma thromboplastin antecedent; PTA
Common Name Factor XI
Gene Symbol F11
Biological Activity Specific Activity =372 U/mg; determined by Factor XI clotting assay where 1 U equals the Factor XI activity in 1 mL of normal human plasma.
Conjugate Unconjugated
Species Human
Content And Storage -20°C, Avoid Freeze/Thaw Cycles
Form Liquid
Protein Subtype Native
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