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Invitrogen™ Factor XI Polyclonal Antibody
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Catalog No. PIPA547327
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100 μg
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PIPA547327 100 μg
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Catalog No. PIPA547327 Supplier Invitrogen™ Supplier No. PA547327
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Description

Goat Polyclonal Antibody

In direct ELISAs, approximately 25% cross-reactivity with recombinant mouse F11 is observed and less than 5% cross-reactivity with recombinant human (rh) F7 and rhF10 is observed. Reconstitute at 0.2 mg/mL in sterile PBS.

This gene encodes coagulation factor XI of the blood coagulation cascade. This protein is present in plasma as a zymogen, which is a unique plasma coagulation enzyme because it exists as a homodimer consisting of two identical polypeptide chains linked by disulfide bonds. During activation of the plasma factor XI, an internal peptide bond is cleaved by factor XIIa (or XII) in each of the two chains, resulting in activated factor XIa, a serine protease composed of two heavy and two light chains held together by disulfide bonds. This activated plasma factor XI triggers the middle phase of the intrisic pathway of blood coagulation by activating factor IX. Defects in this factor lead to Rosenthal syndrome, a blood coagulation abnormality.
TRUSTED_SUSTAINABILITY

Specifications

Antigen Factor XI
Applications Immunoprecipitation, Neutralization, Western Blot
Classification Polyclonal
Concentration 0.2 mg/mL
Conjugate Unconjugated
Formulation PBS with 5% trehalose and No Preservative
Gene F11
Gene Accession No. P03951
Gene Alias 1600027G01Rik; AI503996; Cf11; Coagulation factor XI; Coagulation factor XIa heavy chain; Coagulation factor XIa light chain; F11; FXI; LRRGT00086; plasma thromboplastin antecedent; PTA
Gene Symbols F11
Host Species Goat
Immunogen Mouse myeloma cell line NS0-derived recombinant human Coagulation Factor XI Glu19-Val625.
Purification Method Antigen affinity chromatography
Quantity 100 μg
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 2160
Target Species Human
Content And Storage -20°C, Avoid Freeze/Thaw Cycles
Product Type Antibody
Form Lyophilized
Isotype IgG
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