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Invitrogen™ Factor XII Light chain Monoclonal Antibody (C6B7)
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Catalog No. PIMA126322
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125 μg
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Catalog No. Quantity
PIMA126322 125 μg
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Catalog No. PIMA126322 Supplier Invitrogen™ Supplier No. MA126322
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Description

Mouse Monoclonal Antibody

Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.

This gene encodes coagulation factor XII which circulates in blood as a zymogen. This single chain zymogen is converted to a two-chain serine protease with an heavy chain (alpha-factor XIIa) and a light chain. The heavy chain contains two fibronectin-type domains, two epidermal growth factor (EGF)-like domains, a kringle domain and a proline-rich domain, whereas the light chain contains only a catalytic domain. On activation, further cleavages takes place in the heavy chain, resulting in the production of beta-factor XIIa light chain and the alpha-factor XIIa light chain becomes beta-factor XIIa heavy chain. Prekallikrein is cleaved by factor XII to form kallikrein, which then cleaves factor XII first to alpha-factor XIIa and then to beta-factor XIIa. The active factor XIIa participates in the initiation of blood coagulation, fibrinolysis, and the generation of bradykinin and angiotensin. It activates coagulation factors VII and XI. Defects in this gene do not cause any clinical symptoms and the sole effect is that whole-blood clotting time is prolonged.
TRUSTED_SUSTAINABILITY

Specifications

Antigen Factor XII Light chain
Applications ELISA, Western Blot
Classification Monoclonal
Clone C6B7
Concentration 3 mg/mL
Conjugate Unconjugated
Formulation PBS with no preservative; pH 7.4
Gene F12
Gene Accession No. P00748, Q80YC5
Gene Alias Beta-factor XIIa part 1; beta-factor XIIa part 2; Coagulation factor XII; coagulation factor XII (Hageman factor); coagulation factor XIIa heavy chain; Coagulation factor XIIa light chain; F12; Factor 12; Factor12; FXII; HAE3; HAEX; HAF; Hageman factor
Gene Symbols F12
Host Species Mouse
Immunogen Purified human Factor XII.
Purification Method Protein G
Quantity 125 μg
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 2161, 58992
Target Species Human, Mouse
Content And Storage Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Product Type Antibody
Form Liquid
Isotype IgG1
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Safety and Handling

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