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FANCD2 Rabbit anti-Human, Polyclonal, Bethyl Laboratories

Catalog No. 501561961
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50-156-1961 100 μL
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Catalog No. 50-156-1961 Supplier Bethyl Laboratories, Inc Supplier No. A302174A
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Description

Rabbit Polyclonal Antibody

The recommended shelf life for this product is 1 year from date of receipt. Application Note: For IHC, epitope retrieval with citrate buffer pH 6.0 is recommended for FFPE tissue sections. Based on 100% sequence identity, this antibody is predicted to react with Monkey and Gorilla

FANCD2 (Fanconi anemia group D2 protein) is required for maintece of chromosomal stability. It promotes accurate and efficient pairing of homologs during meiosis. FANCD2 is involved in the repair of DNA double-stranded breaks, both by homologous recombination and single-stranded annealing. It is required for the targeting/stabilization of BLM to non-centromeric abnormal structures induced by replicative stress. FANCD2 promotes BRCA2/FANCD1 loading onto damaged chromatin. Defects in the FANCD2 gene result in Fanconi anemia complementation group D2. This disorder affects all bone marrow elements resulting in anemia, leukopenia, and thrombopenia.

Specifications

Antigen FANCD2
Applications Immunohistochemistry, Immunoprecipitation, Western Blot
Classification Polyclonal
Concentration 0.2 mg/ml
Conjugate Unconjugated
Formulation TBS with 0.1% BSA and 0.09% sodium azide
Gene FANCD2
Gene Accession No. Q9BXW9
Gene Alias FA4, FACD, FAD, FAD2, FANCD, FANCONI ANEMIA COMPLEMENTATION GROUP D, FANCONI PANCYTOPENIA TYPE 4
Gene Symbols FANCD2
Host Species Rabbit
Immunogen Between 1401 and 1451
Purification Method Antigen affinity chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 2177
Target Species Human
Content And Storage 4° C
Product Type Antibody
Form Liquid
Isotype IgG
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