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  6. Invitrogen™ Fc Receptor Binding Inhibitor Polyclonal Antibody, Functional Grade, eBioscience™, Invitrogen™ 

Invitrogen™ Fc Receptor Binding Inhibitor Polyclonal Antibody, Functional Grade, eBioscience™, Invitrogen™

Catalog No. p-7218349
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16-916-138 5 mg
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Catalog No. 16-916-138 Supplier Invitrogen™ Supplier No. 16916138
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Description

Polyclonal Antibody

The human FcgammaR-binding inhibitor can be used to inhibit the non-specific Fc-gamma receptor (FcgammaR)-mediated binding of mouse monoclonal antibodies used for flow cytometric analysis of human tissue. Four different classes of Fcgamma receptors have been identified: FcgammaRI (CD64), FcgammaRII (CD32), and FcgammaRIII (CD16), and they are expressed at varying levels in multiple cell lineages including high expression in myeloid, granulocyte and B cells. The biological function of the FcgammaR, including initiation of endocytosis, phagocytosis and antigen presentation, is elicited upon binding of host-immunoglobulin. The extent to which mouse monoclonal antibodies will bind to human FcgammaR varies depending on the isotype of the MAb. Furthermore, different monoclonal antibodies of the same isotype will display different binding to human FcgammaRs.

Four different classes of Fcy receptors have been identified: FcyRI (CD64), FcyRII (CD32), and FcyRIII (CD16), and they are expressed at varying levels in multiple cell lineages including high expression in myeloid, granulocyte and B cells. The biological function of the FcyR, including initiation of endocytosis, phagocytosis and antigen presentation, is elicited upon binding of host-immunoglobulin. The extent to which mouse monoclonal antibodies will bind to human FcyR varies depending on the isotype of the monoclonal antibody. Furthermore, different monoclonal antibodies of the same isotype will display different binding to human FcyRs.
TRUSTED_SUSTAINABILITY

Specifications

Antigen Fc Receptor Binding Inhibitor
Applications Control, Flow Cytometry, Functional Assay
Classification Polyclonal
Concentration 20 μL/Test
Conjugate Functional Grade
Formulation PBS with no preservative; pH 7.2
Gene Alias Fc blocking; FcR BI; FcR Inhibitor
Host Species Not Available
Purification Method Affinity chromatography
Quantity 5 mg
Regulatory Status RUO
Primary or Secondary Primary
Target Species Human
Content And Storage 4°C
Product Type Antibody
Form Liquid
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Safety and Handling

WARNING: Cancer and Reproductive Harm - www.P65Warnings.ca.gov
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