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Apexbio Technology LLC FCCP(Synonyms: Carbonyl cyanide 4-(trifluoromethoxy)phenylhydrazone), 10mg, CAS: 370-86-5.
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Supplier:  Apexbio Technology LLC B500410

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FCCP (CAS 370-86-5) chemically known as carbonyl cyanide p-trifluoromethoxyphenylhydrazone is a lipophilic mitochondrial uncoupler frequently used in cellular biology research It functions by transporting protons across mitochondrial membranes dissipating the proton gradient essential for ATP synthesis FCCP exhibits potent inhibitory activity (IC 0 51 M in T47D cells) effectively disrupting oxidative phosphorylation Experimentally FCCP increases cellular oxygen consumption and suppresses hypoxia-inducible factors (HIF-1 and HIF-2 ) reducing downstream gene expression such as VEGF In rodent embryos FCCP impairs mitochondrial function resulting in decreased ATP production lower birth weight and altered metabolic phenotypes in offspring highlighting its utility in studying metabolic regulation and mitochondrial biology

Catalog No. 50-000-59996


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