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Invitrogen™ FDC Monoclonal Antibody (CNA.42), eBioscience™, Invitrogen™

Catalog No. 5013937
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50-139-37 25 μg
50-139-38 100 μg
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Catalog No. 50-139-37 Supplier Invitrogen™ Supplier No. 14996880
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Description

Mouse Monoclonal Antibody

Description: The monoclonal antibody CNA.42 recognizes a unique carbohydrate epitope found on follicular dendritic cells (FDCs) from a variety of species. FDCs are large cells in germinal centers (GCs) of primary and lymphoid tissues. They present non-processed antigen and switch off apoptosis of B cells through a selection process resulting in selection of memory B cells. FDCs express many B cell markers such as CD21 (long isoform), CD23 and CD35. A role for FDCs as been shown in various infectious diseases such as AIDS and transmissible spongiform encephalitis. Staining with this CNA.42 monoclonal antibody is mainly restricted to the plasma membrane but in limited cases may also be cytoplasmic (as seen in mast cells). This monoclonal has been shown to be a useful reagent for both flow cytometry and IHC analysis. Applications Reported: This CNA.42 antibody has been reported for use in flow cytometric analysis, immunoblotting (WB), and immunohistochemistry on frozen and formalin-fixed paraffin embedded tissue sections. Applications Tested: This CNA.42 antibody has been tested by flow cytometric of a human cell line and western blotting. This can be used at less than or equal to 0.5 μg per million cells in a 100 μL total staining volume or 2 μg/mL (for western blotting). The antibody has also been tested by immunohistochemistry on formalin-fixed paraffin embedded human tonsil using high pH antigen antigen retrieval.

FDCs are large cells in germinal centers (GCs) of primary and lymphoid tissues. They present non-processed antigen and switch off apoptosis of B cells through a selection process resulting in selection of memory B cells. FDCs express many B cell markers such as CD21 (long isoform), CD23 and CD35. A role for FDCs as been shown in various infectious diseases such as AIDS and transmissible spongiform encephalitis.
TRUSTED_SUSTAINABILITY

Specifications

Antigen FDC
Applications Flow Cytometry, Immunohistochemistry (Frozen), Immunohistochemistry (Paraffin), Western Blot
Classification Monoclonal
Clone CNA.42
Concentration 0.5 mg/mL
Conjugate Unconjugated
Formulation PBS with 0.09% sodium azide; pH 7.2
Gene Alias Dendritic Cells; FDC
Host Species Mouse
Purification Method Affinity chromatography
Quantity 25 μg
Regulatory Status RUO
Primary or Secondary Primary
Target Species Human
Content And Storage 4°C
Product Type Antibody
Form Liquid
Isotype IgM
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Safety and Handling

WARNING: Cancer and Reproductive Harm - www.P65Warnings.ca.gov

For Research Use Only.

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