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Apexbio Technology LLC Fendiline (hydrochloride) 13636-18-5 5g
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Supplier:  Apexbio Technology LLC C56755000

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Fendiline hydrochloride (CAS 13636-18-5) is a small molecule that functions as both an L-type calcium channel blocker and an antagonist of the 2-adrenergic receptor It demonstrates inhibition of L-type Ca2 currents in cardiac myocytes with an IC50 of 17 M and binds the 2-adrenergic receptor with a Kd of 2 6 M Fendiline disrupts K-Ras nanoclustering and impedes K-Ras localization to the plasma membrane (IC50 9 64 M) attenuating downstream Ras signaling and proliferation in cancer cell lines harboring oncogenic Ras mutations It has also been clinically investigated as an anti-anginal agent Fendiline is employed in research exploring calcium signaling adrenergic pathways K-Ras-dependent oncogenesis and cardiovascular pharmacology

Catalog No. 50-000-88969


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