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Apexbio Technology LLC FG2216 223387-75-5 10mM (in 1mL DMSO)
SDP

Supplier:  Apexbio Technology LLC B58515.1

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FG2216 (CAS 223387-75-5) is a potent inhibitor of hypoxia-inducible factor (HIF) prolyl hydroxylase specifically targeting PDH2 with an IC50 of 3 9 M By inhibiting HIF prolyl hydroxylase FG2216 stabilizes HIF promoting transcriptional activation of genes involved in adaptive responses to hypoxia including endogenous erythropoietin (EPO) production In non-human primate studies oral administration of FG2216 resulted in a marked reversible elevation of circulating EPO levels and stimulated erythropoiesis with a modest increase in fetal hemoglobin FG2216 serves as a valuable research tool for investigating HIF regulation oxygen-sensing pathways and erythropoiesis mechanisms

Catalog No. 50-000-93041


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