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Invitrogen™ FGF2 Monoclonal Antibody (FB-8)

Catalog No. MA124682
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100 μL
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MA124682 100 μL
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Catalog No. MA124682 Supplier Invitrogen™ Supplier No. MA124682

Description

Mouse Monoclonal Antibody

Recommended positive controls: recombinant human FGF2. This antibody does not cross react with human acidic FGF. Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.

FGF2 (FGFb, fibroblast growth factor basic) belongs to the fibroblast growth factor (FGF) family, and interacts with high-affinity transmembrane receptors to influence cell proliferation and tissue neovascularization. FGF2 exists as five isoforms with distinct intracellular localizations and functions. The 18 kDa isoform is predominantly cytosolic and acts through cell surface receptors, whereas the 22, 22.5, 24 and 34 kDa isoforms are nuclear and may signal independent of transmembrane receptor pathways. In humans, the gene is located on the q arm of chromosome 4. FGF2 has been implicated in diverse biological processes, such as limb and nervous system development, wound healing, and tumor growth. The mRNA for FGF2 contains multiple polyadenylation sites, and is alternatively translated from non-AUG and AUG initiation codons, resulting in five different isoforms with distinct properties. The CUG-initiated isoforms are localized in the nucleus and are responsible for the intracrine effect, whereas, the AUG-initiated form is mostly cytosolic and is responsible for the paracrine and autocrine effects of this FGF. Diseases associated with FGF2 dysfunction include Kaposi Sarcoma and corneal neovascularization.
TRUSTED_SUSTAINABILITY

Specifications

Antigen FGF2
Applications Dot Blot, ELISA, Neutralization, Radioimmune Assays (RIA), Western Blot, Immunocytochemistry
Classification Monoclonal
Clone FB-8
Concentration 2.3 mg/mL
Conjugate Unconjugated
Formulation PBS with no preservative; pH 7.4
Gene FGF2
Gene Accession No. P03969, P09038
Gene Alias Basic fibroblast growth factor; basic fibroblast growth factor bFGF; bFGF; FGF; fgf basic; Fgf2; Fgf-2; Fgfb; FGF-b; Fibroblast growth factor; fibroblast growth factor 2; fibroblast growth factor 2 (basic); Fibroblast growth factor basic; HBGF-2; Heparin-binding growth factor 2; H-FGF-b-147; H-FGF-b-154; M-FGF-b; Prostatic growth factor; prostatropin
Gene Symbols FGF2
Host Species Mouse
Immunogen Recombinant human FGF2.
Purification Method Purified
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 2247, 281161
Target Species Bovine, Human
Content And Storage Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Product Type Antibody
Form Liquid
Isotype IgG1
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Safety and Handling

WARNING: Reproductive Harm - www.P65Warnings.ca.gov
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