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Invitrogen™ FIR Polyclonal Antibody
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Catalog No. PIPA565956
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PIPA565956 100 μL
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Catalog No. PIPA565956 Supplier Invitrogen™ Supplier No. PA565956
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Description

Rabbit Polyclonal Antibody

Immunogen sequence: VEESDNEWSVP HCFTIYAAQK TIVVAASTRL EKEKWMLDLN SAIQAAKSGG DTAPALPGRT VCTRPPRSPN EVSLEQESED DARGVR Highest antigen sequence identity to the following orthologs - mouse 75%, rat 75%.

FARP2 (FERM, RhoGEF and pleckstrin domain-containing protein 2), also known as PLEKHC3 or FERM domain including RhoGEF (FIR), is a 1,545 amino acid protein that contains one FERM domain, one DH domain and two PH domains. It exists as two alternatively spliced isoforms that are abundantly expressed in brain, lung, and testis as well as in embryonic hippocampal and cortical neurons. FARP2 functions as a Rho-guanine nucleotide exchange factor that activates RAC1 and is thought to regulate neurite remodeling of embryonic neurons. Sema3A binding to neuropilin-1 induces the dissociation of FARP2 from plexin-A1, thereby activating FARP2's Rac GEF activity which is critical for repulsion of outgrowing axons and suppression of neuronal adhesion. Downregulation of the FARP2 gene has been implicated in autism.
TRUSTED_SUSTAINABILITY

Specifications

Antigen FIR
Applications Immunocytochemistry
Classification Polyclonal
Concentration 0.4 mg/mL
Conjugate Unconjugated
Formulation PBS with 40% glycerol and 0.02% sodium azide; pH 7.2
Gene FARP2
Gene Accession No. O94887
Gene Alias AI465173; BC009153; D030026M03Rik; Farp2; FERM domain including RhoGEF; FERM domain-including RhoGEF; FERM, ARH/RhoGEF and pleckstrin domain protein 2; FERM, ARHGEF and pleckstrin domain-containing protein 2; FERM, RhoGEF and pleckstrin domain protein 2; FERM, RhoGEF and pleckstrin domain-containing protein 2; FGD1-related Cdc42-GEF; Fir; FRG; Kiaa0793; mKIAA0793; PH domain-containing family C member 3; pleckstrin homology domain-containing family C member 3; PLEKHC3
Gene Symbols FARP2
Host Species Rabbit
Immunogen Recombinant Human FIR. Recombinant protein control fragment (Product #RP-106645).
Purification Method Antigen affinity chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 9855
Target Species Human
Content And Storage Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Product Type Antibody
Form Liquid
Isotype IgG
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