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FIS1 Mouse anti-Human, Clone: 2F10E1, Proteintech
SDP

Catalog No. p-7213301 Shop All Proteintech Group Inc Products
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50-173-7053 150 μL
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Catalog No. 50-173-7053 Supplier Proteintech Group Inc Supplier No. 666351IG150UL
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Description

Mouse Monoclonal Antibody

Fis1, a 17KDa integral membrane protein, is a novel member of mitochondrial fission machinery. It consists of a central leucine-zipper domain, a coiled-coil region, a tetratricopeptide repeat domain and a C-terminal transmembrane domain. It is a human orthologue of Fis1p (S.cerevisiae) and is localized in the outer mitochondrial membrane. Fis1 acts as a pro-apoptotic factor and plays a vital role in the regulation of mitochondrial fission. It interacts with DLP1 and Mdv1p and facilitates Dnm1p recruitment to the functional fission complex, thereby inducing apoptosis. Role of Fis1 has also been implicated in growth and division of peroxisomes. Loss of Fis1 inhibits apoptosis and results in elongation of mammalian mitochondria.

Specifications

Antigen FIS1
Applications Immunocytochemistry, Immunofluorescence, Immunohistochemistry (Paraffin), Western Blot
Classification Monoclonal
Clone 2F10E1
Concentration 1 mg/mL
Conjugate Unconjugated
Formulation PBS with 50% glycerol and 0.1% sodium azide; pH 7.3
Gene FIS1
Gene Accession No. Q9Y3D6
Gene Alias CGI 135, FIS1, FIS1 homolog, hFis1, TPR repeat protein 11, TTC11
Gene Symbols FIS1
Host Species Mouse
Immunogen FIS1 Fusion Protein Ag1409
Purification Method Protein G
Quantity 150 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 51024
Target Species Human
Content And Storage -20°C
Product Type Antibody
Form Liquid
Isotype IgG1
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