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FIS1 Polyclonal Antibody, Invitrogen™

Catalog No. 01676674
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Catalog No. Quantity
01-676-674 200 μL
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Catalog No. 01-676-674 Supplier Thermo Scientific Supplier No. PA141082

Description

Rabbit Polyclonal Antibody

This antibody is predicted to react with rat, chimp, and canine based on sequence homology. Suggested positive control: antigen standard for FIS1 (transient overexpression lysate), 3T3 or Hela whole cell lysate.

Fis1, a 17KDa integral membrane protein, is a novel member of mitochondrial fission machinery. It consists of a central leucine-zipper domain, a coiled-coil region, a tetratricopeptide repeat domain and a C-terminal transmembrane domain. It is a human orthologue of Fis1p (S.cerevisiae) and is localized in the outer mitochondrial membrane. Fis1 acts as a pro-apoptotic factor and plays a vital role in the regulation of mitochondrial fission. It interacts with DLP1 and Mdv1p and facilitates Dnm1p recruitment to the functional fission complex, thereby inducing apoptosis. Role of Fis1 has also been implicated in growth and division of peroxisomes. Loss of Fis1 inhibits apoptosis and results in elongation of mammalian mitochondria.
TRUSTED_SUSTAINABILITY

Specifications

Antigen FIS1
Applications ELISA, Immunocytochemistry, Immunohistochemistry (Paraffin), Western Blot
Classification Polyclonal
Concentration Conc. Not Determined
Conjugate Unconjugated
Formulation whole serum diluted in PBS with 0.05% BSA and 0.05% sodium azide
Gene FIS1
Gene Accession No. P84817, Q9CQ92, Q9Y3D6
Gene Alias 2010003O14Rik; CGI-135; Fis1; fis1 {ECO:0000250; FIS1 homolog; fission 1 (mitochondrial outer membrane) homolog; fission 1 (mitochondrial outer membrane) homolog (S. cerevisiae); fission 1 (mitochondrial outer membrane) homolog (yeast); fission, mitochondrial 1; H_NH0132A01.6; hFis1; Mitochondrial fission 1 protein; mitochondrial fission molecule; rFis1; tetratricopeptide repeat domain 11; tetratricopeptide repeat protein 11; TPR repeat protein 11; TTC11; UniProtKB:Q9Y3D6}
Gene Symbols FIS1
Host Species Rabbit
Immunogen Synthetic peptide corresponding to residues 11-25 of human Fis1.
Quantity 200 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 288584, 51024, 66437
Target Species Human, Mouse, Rat
Content And Storage Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Product Type Antibody
Form Liquid
Isotype IgG
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Safety and Handling

WARNING: Cancer - www.P65Warnings.ca.gov
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