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Enzo Life Sciences FK-866 (5mg). CAS: 658084-64-1
Supplier: Enzo Life Sciences ALX270501M005
Selective inhibitor of the nicotinamide pathway dependent NAD+synthesis, causing NAD+ depletion. Highly specific, non-competitive inhibitor of nicotinamide phosphoribosyltransferase (NAMPT/NAPRT) for both the enzyme/substrate complex and the free enzyme (Ki=0.4 nM and Ki´=0.3 nM, respectively). NAD+ depletion by FK-866 directs delayed cell death by apoptosis in Hep-G2 human liver carcinoma cells (IC50=~1 nM). Causes premature senescence in normal human smooth muscle cells. Induces autophagy in SH-SY5Y neuroblastoma cells, as indicated by the formation of LC3-positive vesicles. Alternative name: K 22.175, N-[4-(1-benzoyl-4-piperidinyl)butyl]-3-(3-pyridinyl)-2E-propenamide. Purity: ≥98% (NMR). Solubility: Soluble in 100% ethanol, dimethyl formamide (40mg/ml) or DMSO (25mg/ml); sparingly soluble in aqueous buffers. Long Term Storage: -20°C.
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