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FK 866 hydrochloride (Visfatin), Tocris Bioscience™

Catalog No. 480810
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Catalog No.
48-081-0 10mg
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Catalog No. 48-081-0 Supplier R&D Systems Supplier No. 4808/10
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Description

Non-competitive and potent NAMPT inhibitor; induces apoptosis and autophagy

Non-competitive and potent inhibitor of NAMPT (nicotinamide phosphoribosyltransferase, PBEF1) (Ki = 0.3 nM); inhibits NAD biosynthesis. Induces delayed cell death by apoptosis in HepG2 human liver carcinoma cells (IC50 ∽1 nM). Induces apoptosis in four different neuroblastoma cell lines; also induces autophagy in SH-SY5Y cells. Potentiates the cytotoxic effects induced by etoposide (Cat. No. 1226) and cisplatin (Cat. No. 2251).

Specifications

CAS 2727965-45-7
Molecular Formula C24H30ClN3O2
Quantity 10 mg
Synonym 2-(E)-N-[4-(1-Benzoyl-4-piperidinyl)butyl]-3-(3-pyridinyl)-2-propenamide hydrochloride
InChI Key MULSIBUGDPOSHV-CALJPSDSSA-N
SMILES Cl.O=C(NCCCCC1CCN(CC1)C(=O)C1=CC=CC=C1)\C=C\C1=CC=CN=C1
IUPAC Name (2E)-N-[4-(1-benzoylpiperidin-4-yl)butyl]-3-(pyridin-3-yl)prop-2-enamide hydrochloride
Molecular Weight (g/mol) 427.97
Formula Weight 427.97
Chemical Name or Material FK 866 hydrochloride (Visfatin)

Safety and Handling

Recommended Storage Store at -20°C
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