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FK 866 hydrochloride (Visfatin), Tocris Bioscience™
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10mg
Description
Non-competitive and potent inhibitor of NAMPT (nicotinamide phosphoribosyltransferase, PBEF1) (Ki = 0.3 nM); inhibits NAD biosynthesis. Induces delayed cell death by apoptosis in HepG2 human liver carcinoma cells (IC50 ∽1 nM). Induces apoptosis in four different neuroblastoma cell lines; also induces autophagy in SH-SY5Y cells. Potentiates the cytotoxic effects induced by etoposide (Cat. No. 1226) and cisplatin (Cat. No. 2251).
Specifications
Specifications
CAS | 2727965-45-7 |
Molecular Formula | C24H30ClN3O2 |
Quantity | 10 mg |
Synonym | 2-(E)-N-[4-(1-Benzoyl-4-piperidinyl)butyl]-3-(3-pyridinyl)-2-propenamide hydrochloride |
InChI Key | MULSIBUGDPOSHV-CALJPSDSSA-N |
SMILES | Cl.O=C(NCCCCC1CCN(CC1)C(=O)C1=CC=CC=C1)\C=C\C1=CC=CN=C1 |
IUPAC Name | (2E)-N-[4-(1-benzoylpiperidin-4-yl)butyl]-3-(pyridin-3-yl)prop-2-enamide hydrochloride |
Molecular Weight (g/mol) | 427.97 |
Formula Weight | 427.97 |
Chemical Name or Material | FK 866 hydrochloride (Visfatin) |
Safety and Handling
Recommended Storage | Store at -20°C |
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