Invitrogen™ FK506 Monoclonal Antibody (4C12)

Mouse Monoclonal Antibody

Supplier:  Invitrogen™ MA549653

Catalog No. PIMA549653

Description

Antibody tested in indirect ELISA.

Tacrolimus is a macrolide isolated from the culture broth of a strain of Streptomyces tsukubaensis that has strong immunosuppressive activity in vivo and prevents the activation of T-lymphocytes in response to antigenic or mitogenic stimulation in vitro. Tacrolimus binds to the FKBP-12 protein and forms a complex with calcium-dependent proteins, thereby inhibiting calcineurin phosphatase activity and resulting in decreased cytokine production. Tacrolimus possesses similar immunosuppressive properties to cyclosporine, but is more potent. [National Center for Biotechnology Information. PubChem Compound Database; CID=445643].

Specifications

• Antigen: FK506
• Classification: Monoclonal
• Concentration: 4.2 mg/mL
• Formulation: PBS with 0.09% sodium azide; pH 7.4
• Host Species: Mouse
• Purification Method: Protein G
• Regulatory Status: RUO
• Target Species: Chemical
• Product Type: Antibody
• Isotype: IgG

• Applications: ELISA, Immunohistochemistry, Lateral Flow, SDS-Page
• Clone: 4C12
• Conjugate: Unconjugated
• Gene Alias: C44H69NO12; FK-506; Fujimycin; Tacrolimus
• Immunogen: Conjugate of TRL hapten and KLH.
• Quantity: 200 μg
• Primary or Secondary: Primary
• Content And Storage: -20°C, Avoid Freeze/Thaw Cycles
• Form: Liquid