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Invitrogen™ FKBP15 Polyclonal Antibody
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Catalog No. PIPA5115237
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PIPA5115237 100 μL
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Catalog No. PIPA5115237 Supplier Invitrogen™ Supplier No. PA5115237
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Description

Rabbit Polyclonal Antibody

Antibody detects endogenous levels of total FKBP135.

FKBP15, also known as FKBP133, is a member of the FK506-binding protein family, a group of proteins initially identified as immunophilins, targets for the immunosupressant drugs FK506 and Rapamycin. FKBP15 is expressed in the developing nervous system and contains a domain similar to Wiskott-Aldrich syndrome protein homology region 1 (WH1) in addition to the FK506-binding protein motif. FKBP15 is distributed along the axonal shafts and partially co-localizes with F-actin in the growth cones of dorsal root ganglion neurons; overexpression of FKBP15 resulted in the number of filopodia in transfected neurons, suggesting that FKBP15 modulates growth cone behavior. FKBP15 has also been shown to associate with both microtubules and the actin filament systems and disruption of its expression by RNAi resulted in delayed transport of early endosomes in HeLa cells indicating that FKBP15 is also involved in the transport of early endosomes. At least three isoforms of FKBP15 are known to exist.
TRUSTED_SUSTAINABILITY

Specifications

Antigen FKBP15
Applications Western Blot
Classification Polyclonal
Concentration 1 mg/mL
Conjugate Unconjugated
Formulation PBS with 50% glycerol and 0.02% sodium azide
Gene FKBP15
Gene Accession No. Q5T1M5, Q6P9Q6
Gene Alias 133 kDa FK506-binding protein; 133 kDa FKBP; BB131447; C430014M02Rik; FK506 binding protein 15; FK506 binding protein 15, 133kDa; FK506-binding protein 133; FK506-binding protein 133kDa; FK506-binding protein 15; FKBO133; Fkbp133; FKBP-133; FKBP15; FKBP-15; Kiaa0674; mKIAA0674; PPP1R76; protein phosphatase 1, regulatory subunit 76; RGD1304816; WAFL; WASP and FKBP-like; WASP- and FKBP-like protein; WASP and FKBP-like protein
Gene Symbols FKBP15
Host Species Rabbit
Immunogen A synthesized peptide derived from human FKBP15(Accession Q5T1M5), corresponding to amino acid residues K48-A98.
Purification Method Affinity chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 23307, 338355, 362528
Target Species Human, Mouse, Rat
Content And Storage -20°C
Product Type Antibody
Form Liquid
Isotype IgG
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