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Invitrogen™ FKBP4 Monoclonal Antibody (425123)
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Catalog No. MA561386
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MA561386 100 μg
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Catalog No. MA561386 Supplier Invitrogen™ Supplier No. MA561386
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Description

Rat Monoclonal Antibody

Reconstitute at 0.5 mg/mL in sterile PBS.

FKBP4, encoding FK506-binding protein 4, is part of the immunophilin family and plays roles in cellular processes like protein folding and trafficking. The FKBP4 gene is located on chromosome 12, where it encodes a protein involved in modulating the androgen receptor signaling pathway and has been implicated in various cancers, including non-small-cell lung cancer (NSCLC) and hepatocellular carcinoma (HCC). Structural variants of FKBP4 found through exome sequencing have shown potential deleterious effects on protein function. This gene is associated with cell proliferation, apoptosis, migration, and invasion in cancer cells. FKBP4 also influences metabolic processes, such as glycolysis, thereby contributing to cancer cell survival and growth. Importantly, FKBP4 has a role in disorders of sexual development due to its regulatory interaction with hormone signaling pathways.
TRUSTED_SUSTAINABILITY

Specifications

Antigen FKBP4
Applications Immunohistochemistry (Paraffin), Western Blot
Classification Monoclonal
Clone 425123
Concentration 0.5 mg/mL
Conjugate Unconjugated
Formulation PBS with trehalose and no preservative
Gene FKBP4
Gene Accession No. Q02790
Gene Alias 51 kDa FK506-binding protein; 52 kDa FK506-binding protein; 52 kDa FKBP; 59 kDa immunophilin; 59kDa; AL022792; AW208983; FK506 binding protein 4; FK506 binding protein 4, 59kDa; FK506 binding protein 52; FK506-binding protein 4; FK506-binding protein 4 (59kD); FKBP prolyl isomerase 4; Fkbp4; FKBP-4; FKBP51; FKBP52; FKBP-52; FKBP52 protein; FKBP59; Fkpb52; HBI; HSP binding immunophilin; Hsp56; hsp90 binding protein; HSP-binding immunophilin; immunophilin FKBP52; p52; P59; p59 protein; peptidylprolyl cis-trans isomerase; peptidyl-prolyl cis-trans isomerase FKBP4; Peptidyl-prolyl cis-trans isomerase FKBP4, N-terminally processed; PPIase; PPIase FKBP4; rotamase; T-cell FK506-binding protein, 59kD
Gene Symbols FKBP4
Host Species Rat
Immunogen E. coli-derived recombinant human FKBP52, Met1-Ala459.
Purification Method Protein A/G
Quantity 100 μg
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 2288
Target Species Human
Content And Storage Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Product Type Antibody
Form Lyophilized
Isotype IgG1
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