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AdipoGen Flibanserin
SDP

Supplier:  AdipoGen CDXF0337M025

Encompass_Preferred

Chemical. CAS 167933-07-5. Formula C20H21F3N4O. MW 390.4. Synthetic. Flibanserin is a full agonist of the serotonin 5-HT1A receptor and an antagonist of 5-HT2A Ki=1nm and 49nM, respectively. It also binds to dopamine D4 receptors with Ki values ranging from 4-24nM, but demonstrates no affinity for the other 5-HT subtypes or other neurotransmitter receptors. Multifunctional serotonergic ligands like flibanserin that can enhance downstream release of dopamine and norepinephrine while concomitantly reducing serotonin release in the brain circuits that mediate symptoms of reduced sexual interest and desire, are being studied clinically for therapeutic potential to improve sexual functioning. Flibanserin was investigated as a novel, non-hormonal treatment for pre-menopausal women with Hypoactive Sexual Desire Disorder HSDD. Flibanserin was also found to reduce L-DOPA-induced dyskinesia in a model of Parkinson‘s Disease.

Catalog No. 50-256-0854


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