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Apexbio Technology LLC Flufenamic acid 530-78-9 50mg
Supplier: Apexbio Technology LLC B176050
Flufenamic acid (CAS 530-78-9) is a small-molecule inhibitor targeting cyclooxygenase (COX) enzymes and TEAD transcription factors It is designed to inhibit COX-mediated prostaglandin synthesis and block TEAD-YAP-dependent signaling thereby regulating inflammatory responses and gene transcription Flufenamic acid exerts its biological activity primarily through inhibition of COX enzymes and blockade of ion channels including chloride channels (IC50 10 20 M) and L-type calcium channels (IC50 10 M) as well as activation of specific potassium channels The compound also binds the YBD domain of TEAD2 inhibiting YAP-TEAD pathway-dependent cellular proliferation and migration Based on these pharmacological properties flufenamic acid holds research potential in studies of inflammatory pathways ion channel physiology electrophysiological responses and TEAD-mediated signaling
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