Invitrogen™ FMNL2 Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA552148

Catalog No. PIPA552148

Description

Immunogen sequence: ERVEELEENI SHLSEKLQDT ENEAMSKIVE LEKQLMQRNK ELDVVREIYK DANTQVHTLR KMVKEKEEAI QRQSTLEKKI HELEKQGTIK IQKKGDGDIA ILPVVASGTL SMGSEVVAGN SVGP Highest antigen sequence identity to the following orthologs: Mouse - 94%, Rat - 95%.

Formin-like protein 2 is a cytoplasmic phosphoprotein belonging to the formin homology domain containing protein family and has a DAD (diaphanous autoregulatory domain), FH2 (formin homology 2) domain, and GBD/FH3 (Rho GTPase-binding/formin homology 3) domain. The exact function of FMNL2 is yet to be known but reports suggest that it may have a role in the Wnt signaling pathway. Formin-related proteins are also known to play an important role in morphogenesis, cytokinesis and cell polarity. Several alternatively spliced transcript variants have been described but their full-length nature is not yet determined. It is also known to be associated with a diffuse-type gastric cancer, breast cancer, chondrosarcoma, melanoma, and glioblastoma. FMNL2 might be implicated in polarity control, invasion, migration or metastasis through actin filament nucleation and may be regulated by Rho family GTPase.

Specifications

• Antigen: FMNL2
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: FMNL2
• Gene Alias: 5430425K04Rik; FHOD2; FMNL2; formin homology 2 domain containing 2; formin homology 2 domain-containing protein 2; formin like 2; formin-like 2; formin-like domain containing protein MAN; formin-like protein 2; Kiaa1902; Man; protein Man
• Host Species: Rabbit
• Purification Method: Antigen Affinity Chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 114793
• Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
• Form: Liquid

• Applications: Immunohistochemistry (Paraffin), Western Blot, Immunocytochemistry
• Concentration: 0.1 mg/mL
• Formulation: PBS with 40% glycerol and 0.02% sodium azide; pH 7.2
• Gene Accession No.: Q96PY5
• Gene Symbols: FMNL2
• Immunogen: Recombinant protein corresponding to Human FMNL2. Recombinant protein control fragment (Product #RP-88596).
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG