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Apexbio Technology LLC Fosaprepitant dimeglumine salt 265121-04-8 50mg
Supplier: Apexbio Technology LLC B214550
Fosaprepitant dimeglumine salt (CAS 265121-04-8) also known as MK-0517 or L-758 298 is a selective antagonist of the neurokinin-1 (NK-1) receptor It functions primarily through its active metabolite aprepitant a brain-penetrant NK-1 inhibitor with high affinity thereby effectively suppressing substance P-mediated signaling In preclinical models fosaprepitant dimeglumine salt demonstrates antiemetic activity against cisplatin-induced vomiting In biomedical research it is often investigated alongside corticosteroids (e g dexamethasone) and 5-HT3 antagonists (e g granisetron) for the management of chemotherapy-induced nausea and vomiting (CINV)
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