Fostriecin sodium salt, Tocris Bioscience™

Description

Potent PP2A and PP4 inhibitor

Potent inhibitor of protein phosphatase types 2A (PP2A) and 4 (PP4) with IC50 values of 1.5 nM and 3 nM respectively. Also exhibits weaker inhibition of topoisomerase II (IC50 = 40 μM) and protein phosphatase type 1 (PP1) (IC50 = 131 μM) with no apparent inhibition of protein phosphatase type 2B (PP2B). Active in vivo. Originally identified as an antitumor antibiotic from Streptomyces pulveraceous.

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Specifications

Chemical Identifiers

• CAS: 87860-39-7
• Molecular Formula: C19H26NaO9P
• Molecular Weight (g/mol): 452.372
• InChI Key: XBUIKNRVGYFSHL-SOAGNPLSSA-M
• Synonym: fostriecin sodium salt
• PubChem CID: 124080892
• IUPAC Name: sodium;[(1Z,3R,4R,6R,7E,9E,11E)-3,6,13-trihydroxy-3-methyl-1-[(2R)-6-oxo-2,3-dihydropyran-2-yl]trideca-1,7,9,11-tetraen-4-yl] hydrogen phosphate
• SMILES: CC(C=CC1CC=CC(=O)O1)(C(CC(C=CC=CC=CCO)O)OP(=O)(O)[O-])O.[Na+]

• Quantity: 50 μg
• Formula Weight: 452.37
• Percent Purity: >98%
• Chemical Name or Material: Fostriecin sodium salt

Safety and Handling

Recommended Storage

Desiccate at -20°C