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Fostriecin sodium salt, Tocris Bioscience™
GSA_VA

Catalog No. 184050U
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50 μg
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Catalog No. Quantity
18-405-0U 50 μg
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Catalog No. 18-405-0U Supplier R&D Systems Supplier No. 1840/50U
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Description

Potent PP2A and PP4 inhibitor

Potent inhibitor of protein phosphatase types 2A (PP2A) and 4 (PP4) with IC50 values of 1.5 nM and 3 nM respectively. Also exhibits weaker inhibition of topoisomerase II (IC50 = 40 μM) and protein phosphatase type 1 (PP1) (IC50 = 131 μM) with no apparent inhibition of protein phosphatase type 2B (PP2B). Active in vivo. Originally identified as an antitumor antibiotic from Streptomyces pulveraceous.

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Chemical Identifiers

CAS 87860-39-7
Molecular Formula C19H26NaO9P
Molecular Weight (g/mol) 452.372
InChI Key XBUIKNRVGYFSHL-SOAGNPLSSA-M
Synonym fostriecin sodium salt
PubChem CID 124080892
IUPAC Name sodium;[(1Z,3R,4R,6R,7E,9E,11E)-3,6,13-trihydroxy-3-methyl-1-[(2R)-6-oxo-2,3-dihydropyran-2-yl]trideca-1,7,9,11-tetraen-4-yl] hydrogen phosphate
SMILES CC(C=CC1CC=CC(=O)O1)(C(CC(C=CC=CC=CCO)O)OP(=O)(O)[O-])O.[Na+]

Specifications

Quantity 50 μg
Formula Weight 452.37
Percent Purity >98%
Chemical Name or Material Fostriecin sodium salt

Safety and Handling

Recommended Storage Desiccate at -20°C
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