Invitrogen™ FOXC1 Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA1807

Catalog No. PIPA1807

Description

PA1-807 detects FOXC1 from human and mouse samples. PA1-807 has been successfully used in Western blot procedures. By Western blot, PA1-807 detects a ~50 kDa band representing FOXC1 from HepG2 cells and mouse kidney cells. This antibody also detects a nonspecific band at ~45 kDa from HepG2 cells, and at ~60 kDa from mouse kidney samples. The PA1-807 immunogen is a synthetic peptide corresponding to residues A(423) V D D P L P D Y S L P(434) of human FOXC1. PA1-807 can be used with blocking peptide PEP-298.

FOXC1 is a protein belonging to the forkhead family of transcription factors which is characterized by a distinct DNA-binding forkhead domain. The specific function of this protein is not known, however, it plays a role in the regulation of FGF19-FGFR4-MAPK pathway to promote both the development and maintenance of anterior segment structures within the eye. Mutations in this gene cause various glaucoma, iridogoniodysgenesis anomaly, Peters anomaly that includes central corneal leukoma, absence of the posterior corneal stroma and Descemetmembrane and Axenfeld-Rieger anomaly characterized by posterior corneal embryotoxon, iris adhesion to the Schwalbe line, hypertelorism, hypoplasia of the malar bones, congenital absence of some teeth and mental retardation.

Specifications

• Antigen: FOXC1
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: FOXC1
• Gene Alias: ARA; ch; congenital hydrocephalus; Fkh1; fkh-1; Fkhl7; forkhead box C1; forkhead box C1 protein; forkhead box protein C1; forkhead, drosophila, homolog-like 7; forkhead/winged helix-like transcription factor 7; forkhead-related activator 3; forkhead-related protein FKHL7; Forkhead-related transcription factor 3; Foxc1; FREAC3; FREAC-3; frkhda; HGNC:3800; IGDA; IHG1; IRID1; Mesoderm/mesenchyme forkhead 1; Mf1; MF-1; Mf4; myeloid factor-delta; RIEG3; Transcription factor FKH-1
• Host Species: Rabbit
• Purification Method: Antigen affinity chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 17300, 2296
• Content And Storage: -20°C, Avoid Freeze/Thaw Cycles
• Form: Liquid

• Applications: ChIP Assay, Western Blot, Immunocytochemistry
• Concentration: 1 mg/mL
• Formulation: PBS with 1 mg/mL BSA and 0.05% sodium azide
• Gene Accession No.: Q12948, Q61572
• Gene Symbols: FOXC1
• Immunogen: Synthetic peptide corresponding to residues A(423) V D D P L P D Y S L P(434) of human FOXC1.
• Quantity: 100 μg
• Primary or Secondary: Primary
• Target Species: Human, Mouse
• Product Type: Antibody
• Isotype: IgG

Safety and Handling

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