FOXO4 Monoclonal Antibody (OTI10F12), TrueMAB™, OriGene

Catalog No.	Quantity
50-168-2252	100 μL

Catalog No. 50-168-2252 Supplier OriGene Supplier No. TA808604

Description

Mouse Monoclonal Antibody

FOXO4 (Forkhead box O4) is encoded by the FOXO4 gene located on the X chromosome. It is also known as AFX1 or MLLT7 (Myeloid/Lymphoid or Mixed-Lineage Leukemia (Trithorax Homolog, Translocated To, 7) and is a member of the O class of forkhead/ winged helix family of transcription factors along with FOXO1, FOXO3 and FOXO6. FOXO4 is abundantly expressed in skeletal muscle and adipose tissue. FOXO4 binds to the Insulin Responsive Element (IRE) and activates downstream targets of Insulin/IGF1 signaling such as IGFBP1. However, the activation of another downstream target of the Insulin/IGF1 pathway, Akt, leads to phosphorylation of FOXO4 on specific Ser/Thr residues. This phosphorylation mediates binding of FOXO4 to 14-3-3 and eventual exit of FOXO4 from the nucleus.

Specifications

• Antigen: FOXO4
• Applications: Western Blot
• Classification: Monoclonal
• Clone: OTI10F12
• Concentration: 1 mg/mL
• Conjugate: Unconjugated
• Formulation: PBS with 1% BSA, 50% glycerol and 0.02% sodium azide
• Gene: FOXO4
• Gene Accession No.: P98177
• Gene Alias: AFX, AFX1, MLLT7
• Gene Symbols: FOXO4
• Host Species: Mouse
• Immunogen: Human recombit protein fragment corresponding to amino acids 206-505 of human FOXO4 produced in E.coli.
• Purification Method: Affinity Chromatography
• Quantity: 100 μL
• Regulatory Status: RUO
• Primary or Secondary: Primary
• Gene ID (Entrez): 4303
• Target Species: Human
• Content And Storage: -20° C, Avoid Freeze/Thaw Cycles
• Product Type: Antibody
• Form: Liquid
• Isotype: IgG1